Chemical Property of Hexahydrocurcumin
Chemical Property:
- Vapor Pressure:2.31E-16mmHg at 25°C
- Melting Point:80-82℃
- Boiling Point:622.6oC at 760 mmHg
- PKA:10.02±0.20(Predicted)
- Flash Point:218.3oC
- PSA：96.22000
- Density:1.226g/cm3
- LogP:3.00050
- Storage Temp.:2-8°C
- Solubility.:Chloroform (Sparingly), Ethyl Acetate (Slightly), DCM, DMSO
- XLogP3:2.7
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:10
- Exact Mass:374.17293854
- Heavy Atom Count:27
- Complexity:442
- Purity/Quality:
-
97% *data from raw suppliers
Hexahydrocurcumin
analytical standard
*data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:COC1=C(C=CC(=C1)CCC(CC(=O)CCC2=CC(=C(C=C2)O)OC)O)O
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Description
Hexahydrocurcumin is a natural product and glucuronide metabolite of curcumin that has anti-inflammatory, antioxidant, and anticancer properties. It reduces prostaglandin E2 (PGE2) production stimulated by phorbol 12-myristate 13-acetate (PMA; ) by 37% in human colonic epithelial cells when used at a concentration of 20 μM. Hexahydrocurcumin (3.125-25 μM) inhibits overproduction of nitric oxide induced by LPS in RAW 264.7 macrophage cells in a concentration-dependent manner. It does not affect LPS-induced cytokine release but inhibits LPS-induced iNOS and COX-2 upregulation and NF-κB activation when used at a concentration of 50 μM. Hexahydrocurcumin prevents the formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer and potentiates the effect of 5-fluorouracil .
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Uses
Hexahydrocurcumin is an intermediate in the synthesis of Gingerenone A (G387500) which is an antifungal and antiparasitic diarylheptenone that is isolated from Zingiber officinale (more commonly known as ginger), a medicinal plant that is used to treat inflammation and musculoskeletal disorders.
