4-Hydroxy-3-methylbenzofuran

Base Information

• Chemical Name: 4-Hydroxy-3-methylbenzofuran
• CAS No.: 3610-15-9
• Molecular Formula: C9H8O2
• Molecular Weight: 148.161
• European Community (EC) Number: 887-378-8
• Nikkaji Number: J891.422B
• Mol file: 3610-15-9.mol

Synonyms:3-methyl-1-benzofuran-4-ol;3610-15-9;4-hydroxy-3-methylbenzofuran;3-methyl-4-hydroxybenzofuran;SCHEMBL2044277;PEUAZQMQTCPVPZ-UHFFFAOYSA-N;AKOS000320330;FT-0716271;EN300-6770799

Chemical Property of 4-Hydroxy-3-methylbenzofuran

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 148.052429494
• Heavy Atom Count: 11
• Complexity: 147

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=COC2=CC=CC(=C12)O

Technology Process of 4-Hydroxy-3-methylbenzofuran

There total 1 articles about 4-Hydroxy-3-methylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

3-(2-bromoallyloxy)-phenol (197086-82-1) → 3-methylbenzofuran-6-ol (3652-66-2) + 4-hydroxy-3-methylbenzofuran (3610-15-9) + recorcinol (108-46-3)

Guidance literature:

With caesium carbonate; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); In N,N-dimethyl acetamide; at 70 ℃; for 72h;

DOI:10.1016/S0040-4039(97)01468-8

Reference yield:

4-hydroxy-3-methylbenzofuran (3610-15-9) → 1-(3-methylbenzofuranyl-4-oxy)-3-1-(N4-phenyl)piperazinyl>propan-2-ol (88737-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / K₂CO₃ / Heating

2: 74 percent / methanol / 6 h / Heating

With potassium carbonate; In methanol;

Reference yield:

4-hydroxy-3-methylbenzofuran (3610-15-9) → 4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester (3781-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; zinc chloride; hydrogen chloride / Erwaermen des Reaktionsprodukts mit Wasser

2: aq.-ethanolic KOH-solution

With hydrogenchloride; potassium hydroxide; diethyl ether; zinc(II) chloride;

DOI:10.1039/jr9510003235

upstream raw materials:

3-(2-bromoallyloxy)-phenol

Downstream raw materials:

1-(3-methylbenzofuranyl-4-oxy)-3-1-(N⁴-phenyl)piperazinyl>propan-2-ol

4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester