Penta-L-alanine

Base Information

• Chemical Name: Penta-L-alanine
• CAS No.: 10183-34-3
• Molecular Formula: C₁₅H₂₇N₅O₆
• Molecular Weight: 373.409
• DSSTox Substance ID: DTXSID50906649
• Mol file: 10183-34-3.mol

Synonyms:Penta-L-alanine;Ala-Ala-Ala-Ala-Ala;10183-34-3;(2R)-2-[[(2R)-2-[2-[2-[[(2R)-2-aminopropanoyl]amino]propanoylamino]propanoylamino]propanoyl]amino]propanoic acid;DTXSID50906649;N-(2-{[2-({2-[(2-Amino-1-hydroxypropylidene)amino]-1-hydroxypropylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxypropylidene)alanine

Chemical Property of Penta-L-alanine

Chemical Property:

• Vapor Pressure: 9E-30mmHg at 25°C
• Melting Point: None °C
• Boiling Point: 822.3°Cat760mmHg
• Flash Point: 451.1°C
• PSA: 179.72000
• Density: 1.244g/cm³
• LogP: -0.29910
• Storage Temp.: -15°C
• Solubility.: Aqueous Acid (Slightly), Water (Slightly)
• XLogP3: -4
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 373.19613360
• Heavy Atom Count: 26
• Complexity: 567

Purity/Quality:

98%,99%, ^*data from raw suppliers

H-Ala-Ala-Ala-Ala-Ala-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C(=O)NC(C)C(=O)NC(C)C(=O)NC(C)C(=O)NC(C)C(=O)O)N
• Isomeric SMILES: C[C@H](C(=O)NC(C)C(=O)NC(C)C(=O)N[C@H](C)C(=O)N[C@H](C)C(=O)O)N

Technology Process of Penta-L-alanine

There total 8 articles about Penta-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-Alanine (338-69-2,25191-17-7,18875-37-1) → ALA8 + di-L-alanine (1948-31-8,110652-05-6,210687-33-5,2392-61-2) + L-ala-L-ala-L-ala (5874-90-8) + tetra-L-alanine (926-78-3,926-79-4,5874-82-8,5874-83-9,5874-84-0,5874-85-1,6062-67-5,6062-68-6,6120-80-5,6618-84-4,6621-00-7,6759-32-6,10145-91-2,14017-24-4,91741-19-4,91741-20-7) + Penta-L-Alanin (10145-97-8,10145-98-9,10145-99-0,10183-35-4,10211-75-3,10251-26-0,10491-09-5,14417-61-9,39870-27-4,10183-34-3) + hexaalanine (10251-27-1,10251-28-2,10251-30-6,10251-31-7,10251-32-8,10413-79-3,10576-91-7,286842-36-2) + C28H49N9O10 (431948-97-9) + 5'-d(AAA AAA A)-3' (103508-54-9)

Guidance literature:

D-Alanine; With phosphorus trichloride; In acetonitrile; for 48h;

With water; In acetonitrile;

DOI:10.1080/10426500701807467

Reference yield:

→ Penta-L-Alanin (10145-97-8,10145-98-9,10145-99-0,10183-35-4,10211-75-3,10251-26-0,10491-09-5,14417-61-9,39870-27-4,10183-34-3)

Guidance literature:

With palladium; N,N-dimethyl-formamide; Hydrogenation;

DOI:10.1021/ja01127a505

Reference yield:

(D-2-bromo-propionyl)-tri-L-alanyl-L-alanine → Penta-L-Alanin (10145-97-8,10145-98-9,10145-99-0,10183-35-4,10211-75-3,10251-26-0,10491-09-5,14417-61-9,39870-27-4,10183-34-3)

Guidance literature:

With ammonia; water; at 37 ℃;

upstream raw materials:

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

L-ala-L-ala-L-ala

tetra-L-alanine

D-Alanine

Downstream raw materials:

hexaalanine

Refernces

• 1、 Graf, Juergen,Nguyen, Phuong H.,Stock, Gerhard,Schwalbe, Harald. "Structure and dynamics of the homologous series of alanine peptides: A joint molecular dynamics/NMR study". . p. 1179 - 1189. Retrieved 2008/04/18.