Pitolisant

Base Information

Chemical Name:Pitolisant
CAS No.:362665-56-3
Molecular Formula:C17H26ClNO
Molecular Weight:295.853
Hs Code.:
UNII:4BC83L4PIY
DSSTox Substance ID:DTXSID30957654
Nikkaji Number:J1.574.747A
Wikipedia:Pitolisant
Wikidata:Q426044
NCI Thesaurus Code:C166747
RXCUI:2197878
Pharos Ligand ID:SGNUZPNGMXH7
Metabolomics Workbench ID:152764
ChEMBL ID:CHEMBL462605
Mol file:362665-56-3.mol

Synonyms:1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine;BF-2549;BF2.649;pitolisant;tiprolisant;Wakix

Suppliers and Price of Pitolisant

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Pitolisant >98%
100 mg
$ 300.00

Crysdot
Pitolisant 98+%
50mg
$ 312.00

Crysdot
Pitolisant 98+%
10mg
$ 72.00

Biosynth Carbosynth
Pitolisant
50 mg
$ 200.00

Biosynth Carbosynth
Pitolisant
100 mg
$ 300.00

Biosynth Carbosynth
Pitolisant
250 mg
$ 450.00

Biosynth Carbosynth
Pitolisant
1 g
$ 850.00

Biosynth Carbosynth
Pitolisant
500 mg
$ 650.00

Biorbyt Ltd
Pitolisant
100 mg
$ 606.90

Arctom
Pitolisant ≥98%
100mg
$ 367.00

Total 53 raw suppliers

Chemical Property of Pitolisant

Chemical Property:

Boiling Point:398.7±32.0 °C(Predicted)
PKA:9.41±0.10(Predicted)
PSA：12.47000
Density:1.056
LogP:4.10310
Storage Temp.:Sealed in dry,Store in freezer, under -20°C
XLogP3:4.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:8
Exact Mass:295.1702921
Heavy Atom Count:20
Complexity:235

Purity/Quality:

97% ^*data from raw suppliers

Pitolisant >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:CNS Drugs
Canonical SMILES:C1CCN(CC1)CCCOCCCC2=CC=C(C=C2)Cl
Recent ClinicalTrials:A Clinical Study to Evaluate the Efficacy and Safety of Pitolisant in the Treatment of EDS in Patients With OSA
Recent EU Clinical Trials:A Multisite Randomized, Double-Blind, Placebo-Controlled Trial
Uses Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor. Pitolisant is also used in the treatment of patients with narcolepsy, excessive daytime sleepiness, cataplexy, disturbed nocturnal sleep, hypnagogic hallucinations and sleep paralysis

Technology Process of Pitolisant

There total 5 articles about Pitolisant which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

: 104-58-5
3-piperidinopropan-1-ol

: 61440-60-6
methanesulfonic acid 3-(4-chlorophenyl)-propyl ester

: 362665-56-3
pitolisant

Guidance literature:: 3-piperidinopropan-1-ol; With sodium hydride; In ISOPROPYLAMIDE; at 50 ℃; for 1h;

methanesulfonic acid 3-(4-chlorophenyl)-propyl ester; In ISOPROPYLAMIDE; at 22 - 25 ℃; for 9h;