4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-YL]pyridine N-oxide

Base Information

Chemical Name:4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-YL]pyridine N-oxide
CAS No.:365430-22-4
Molecular Formula:C17H16N2OS
Molecular Weight:296.393
Hs Code.:
DSSTox Substance ID:DTXSID60462423
Mol file:365430-22-4.mol

Synonyms:4-[2-ETHYL-4-(3-METHYLPHENYL)-1,3-THIAZOL-5-YL]PYRIDINE N-OXIDE;365430-22-4;SCHEMBL3890349;DTXSID60462423;XJTXKRHUWRQQHC-UHFFFAOYSA-N

Suppliers and Price of 4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-YL]pyridine N-oxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-YL]pyridine N-oxide

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:296.09833431
Heavy Atom Count:21
Complexity:333

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1=NC(=C(S1)C2=CC=[N+](C=C2)[O-])C3=CC=CC(=C3)C

Technology Process of 4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-YL]pyridine N-oxide

There total 5 articles about 4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-YL]pyridine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 325769-17-3
2-ethyl-4-(3-methylphenyl)-5-(4-pyridyl)-1,3-thiazole

: 365430-22-4
4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridine 1-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1248/cpb.53.410

Reference yield:

: 21384-43-0
1-(3-methylbenzoyl)-2-methylaziridine

: 365430-22-4
4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridine 1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran; hexane / 1 h / -10 °C

1.2: 65 percent / tetrahydrofuran; hexane / 2 h / -78 °C

2.1: Br₂; AcOH / 3 h / 80 °C

3.1: 59 percent / dimethylformamide / 14 h / 20 °C

4.1: 74 percent / mCPBA / dimethylformamide / 14 h / 20 °C

With bromine; acetic acid; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm050165o

Reference yield:

: 216529-53-2
1-(3-methylphenyl)-2-(pyridin-4-yl)ethanone

: 365430-22-4
4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridine 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: Br₂; AcOH / 3 h / 80 °C

2: 59 percent / dimethylformamide / 14 h / 20 °C

3: 74 percent / mCPBA / dimethylformamide / 14 h / 20 °C

With bromine; acetic acid; 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm050165o