(2-Chlorophenyl)magnesium bromide

Base Information

• Chemical Name: (2-Chlorophenyl)magnesium bromide
• CAS No.: 36692-27-0
• Molecular Formula: C6H4BrClMg
• Molecular Weight: 215.76
• Mol file: 36692-27-0.mol

Synonyms:chlorophenyl magnesium bromide;2-Chlor-phenylmagnesium-bromid;2-chlorophenylmagnesium bromide;(o-chlorophenyl)magnesium bromide;(2-chloro-phenyl)-magnesium bromide;o-chlorophenylmagnesium bromide;

Chemical Property of (2-Chlorophenyl)magnesium bromide

Chemical Property:

• Melting Point: 68.0-69.0 °C
• PSA: 0.00000
• LogP: 2.98580

Purity/Quality:

99% ^*data from raw suppliers

2-Chlorophenylmagnesiumbromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-Chlorophenyl)magnesium bromide

There total 2 articles about (2-Chlorophenyl)magnesium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-1-chlorobenzene (694-80-4) → 2-chlorophenylmagnesium bromide (36692-27-0)

Guidance literature:

With iodine; magnesium; In diethyl ether; Inert atmosphere; Reflux;

DOI:10.1007/s11172-018-2235-z

Reference yield:

→ 2-chlorophenylmagnesium bromide (36692-27-0)

Guidance literature:

Reference yield: 87.0%

2-chlorophenylmagnesium bromide (36692-27-0) + (Z)-methyl 3-(p-toluenesulfonyloxy)but-2-enoate (1029612-18-7) → (Z)-methyl 3-(2-chlorophenyl)-2-butenoate (1029612-69-8)

Guidance literature:

2-chlorophenylmagnesium bromide; With zinc(II) chloride; In tetrahydrofuran; at 0 - 5 ℃; Inert atmosphere;

(Z)-methyl 3-(p-toluenesulfonyloxy)but-2-enoate; With bis(triphenylphosphine)palladium(II) dichloride; In tetrahydrofuran; at 20 - 25 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol800480d

upstream raw materials:

2-bromo-1-chlorobenzene

Downstream raw materials:

o-chlorotriphenylmethanol

9-(2-chloro-phenyl)-fluoren-9-ol

2-Chlorobenzeneboronic acid

2,2-dichloro-1-(2-chlorophenyl)ethanol

Refernces

• 1、 Vasilyeva,Vorobyeva. "Synthesis of trifluoromethylated α-hydroxy acids and their derivatives based on alkyl trifluoropyruvates". . p. 1426 - 1432. Retrieved 2018/10/31.