2-Phenylquinolin-3-amine

Base Information

• Chemical Name: 2-Phenylquinolin-3-amine
• CAS No.: 36710-53-9
• Molecular Formula: C15H12N2
• Molecular Weight: 220.274
• Mol file: 36710-53-9.mol

Synonyms:3-amino-2-phenylquinoline;2-phenyl-3-quinolinamine;2-Amino-3-phenylchinolin;3-Quinolinamine, 2-phenyl-;2-phenyl-[3]quinolylamine;2-Phenyl-[3]chinolylamin;2-phenylquinolin-3-amine;

Chemical Property of 2-Phenylquinolin-3-amine

Chemical Property:

• PSA: 38.91000
• LogP: 4.06520

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Phenylquinolin-3-amine

There total 23 articles about 2-Phenylquinolin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-(2-isocyanophenyl)acetonitrile (17127-85-4) + phenylboronic acid (98-80-6) → 2-phenyl-quinolin-3-ylamine (36710-53-9)

Guidance literature:

With manganese(III) triacetate dihydrate; caesium carbonate; In toluene; at 80 ℃; for 8h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02373

Reference yield: 67.0%

3-nitro-2-phenylquinoline (5443-79-8) → 2-phenyl-quinolin-3-ylamine (36710-53-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1055/s-0031-1289652

Reference yield: 65.0%

N-phenacylpyridinium bromide (16883-69-5) + o-aminobenzaldehyde (529-23-7) → 2-phenyl-quinolin-3-ylamine (36710-53-9)

Guidance literature:

N-phenacylpyridinium bromide; o-aminobenzaldehyde; With pyridine; dmap; In ethanol; for 48h; Heating;

With pyrrolidine; In ethanol; Further stages.; Heating;

DOI:10.1016/j.tet.2004.02.012

upstream raw materials:

2-phenylquinoline-3-carboxamide

3-nitro-2-phenylquinoline

3-benzoylamino-2-phenyl-quinoline-4-carboxylic acid

3-cyclohexylamino-2-phenyl-quinoline-4-carboxylic acid

Downstream raw materials:

2-phenyl-3-acetamidoquinoline

N-(2-phenyl-[3]quinolyl)-benzamide

3-bromo-2-phenylquinoline

3-hydroxy-2-phenylquinoline