Methyl 3-(2-(tert-butoxy)-2-oxoethoxy)benzoate

Base Information

• Chemical Name: Methyl 3-(2-(tert-butoxy)-2-oxoethoxy)benzoate
• CAS No.: 367501-39-1
• Molecular Formula: C14H18O5
• Molecular Weight: 266.294
• Mol file: 367501-39-1.mol

Synonyms:tert-butyl [3-(methoxycarbonyl)phenoxy]acetate;t-butyl [3-(methoxycarbonyl)phenoxy]acetate;3-tert-Butoxycarbonylmethoxy-benzoic acid methyl ester;

Chemical Property of Methyl 3-(2-(tert-butoxy)-2-oxoethoxy)benzoate

Chemical Property:

• PSA: 61.83000
• LogP: 2.19370

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-(2-(tert-butoxy)-2-oxoethoxy)benzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-(2-(tert-butoxy)-2-oxoethoxy)benzoate

There total 3 articles about Methyl 3-(2-(tert-butoxy)-2-oxoethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

bromoacetic acid tert-butyl ester (5292-43-3) + methyl 3-hydroxybenzoate (19438-10-9) → methyl 3-[2-(tert-butoxy)-2-oxoethoxy]benzoate (367501-39-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃;

Reference yield:

3-Carboxyphenol (99-06-9) → methyl 3-[2-(tert-butoxy)-2-oxoethoxy]benzoate (367501-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 93.7 percent / acetyl chloride / 8 h / Heating

2.1: K₂CO₃ / tetrahydrofuran / 1 h

2.2: tetrahydrofuran

With potassium carbonate; acetyl chloride; In tetrahydrofuran;

DOI:10.1021/jm0609869

Reference yield:

→ methyl 3-[2-(tert-butoxy)-2-oxoethoxy]benzoate (367501-39-1)

Guidance literature:

upstream raw materials:

bromoacetic acid tert-butyl ester

methyl 3-hydroxybenzoate

3-Carboxyphenol

Downstream raw materials:

methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-(2,3-dihydro-1-benzofuran-6-yloxy)phenyl}amino)-2-oxoethoxy]benzoate

3-{[6-(2,3-dihydro-1-benzofuran-6-yloxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoic acid

methyl 3-{[6-(2,3-dihydro-1-benzofuran-6-yloxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate monohydrochloride

N-((S)-6-amino-4,5,6,7-tetrahydro-benzothiazol-2-yl)-3-[(4-cyano-phenylcarbamoyl)-methoxy]-benzamide

Refernces

• 1、 -. "INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE". Paragraph 00296. . Retrieved 2016/09/22.
• 2、 -. "PYRIDINE DERIVATIVE". Page/Page column 20. . Retrieved 2012/02/04.