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Technology Process of 5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide

5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide

Base Information
  • Chemical Name:5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide
  • CAS No.:1031602-63-7
  • Molecular Formula:C17H20N4O2S
  • Molecular Weight:344.4
  • Hs Code.:
  • ChEMBL ID:CHEMBL4303547
  • Mol file:1031602-63-7.mol
5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide

Synonyms:UNC3230;1031602-63-7;UNC 3230;5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide;CHEMBL4303547;5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide;SCHEMBL22468228;BCP33007;EX-A3497;BDBM50599593;AKOS002060279;CCG-192274;UNC-3230;NCGC00387258-04;AS-16444;HY-110150;CS-0033010;E78406;A898862;2-anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide

Suppliers and Price of 5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • UNC 3230
  • 10mg
  • $ 460.00
  • TRC
  • UNC3230
  • 10mg
  • $ 190.00
  • Tocris
  • UNC3230 ≥99%(HPLC)
  • 10
  • $ 208.00
  • Tocris
  • UNC3230 ≥99%(HPLC)
  • 50
  • $ 844.00
  • Cayman Chemical
  • UNC3230 ≥95%
  • 50mg
  • $ 665.00
  • Cayman Chemical
  • UNC3230 ≥95%
  • 10mg
  • $ 171.00
  • Cayman Chemical
  • UNC3230 ≥95%
  • 5mg
  • $ 95.00
  • Cayman Chemical
  • UNC3230 ≥95%
  • 1mg
  • $ 38.00
  • Biosynth Carbosynth
  • UNC 3230
  • 50 mg
  • $ 225.00
  • Biosynth Carbosynth
  • UNC 3230
  • 25 mg
  • $ 150.00
Total 10 raw suppliers
Chemical Property of 5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide
Chemical Property:
  • XLogP3:4.2
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:5
  • Rotatable Bond Count:5
  • Exact Mass:344.13069707
  • Heavy Atom Count:24
  • Complexity:450
Purity/Quality:

99%, *data from raw suppliers

UNC 3230 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:
Useful:
  • Canonical SMILES:C1CCC(CC1)C(=O)NC2=C(N=C(S2)NC3=CC=CC=C3)C(=O)N
  • Description Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG). Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2. UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM). It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases. At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.
  • Uses UNC 3230 is a potent inhibitor of PIP5K1C.
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