2-[[4-Chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]-2-methylpropanoic acid

Base Information

• Chemical Name: 2-[[4-Chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]-2-methylpropanoic acid
• CAS No.: 256477-09-5
• Molecular Formula: C14H16ClN5O4S
• Molecular Weight: 385.8
• ChEMBL ID: CHEMBL227421
• Mol file: 256477-09-5.mol

Synonyms:2-(((4-chloro-1-guanidino-7-isoquinolinyl)sulfonyl)amino)isobutyric acid;UK 371,804;UK 371804;UK-371,804;UK-371804;UK371,804;UK371804

Chemical Property of 2-[[4-Chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]-2-methylpropanoic acid

Chemical Property:

• XLogP3: 0.7
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 385.0611529
• Heavy Atom Count: 25
• Complexity: 644

Purity/Quality:

99%, ^*data from raw suppliers

UK-371804 >98% ^*data from reagent suppliers

Safty Information:

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Useful:

• Canonical SMILES: CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl
• Description: UK-371804 is a potent and selectiveurokinase-type plasmogen activator (uPA)inhibitor. It has excellent selectivityover tPA, plasmin, Factor IXa and Xa.In vitro, it is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound modelfollowing topical delivery, it is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. It has the potential for the treatment of chronic dermal ulcers.

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