Technology Process of MRS 2279
There total 6 articles about MRS 2279 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron trichloride; methoxybenzene;
In
dichloromethane;
at 0 ℃;
for 24h;
DOI:10.1021/jm990249v
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 64 percent / Ph3P; DEAD / tetrahydrofuran / 12 h / 20 °C
2.1: 88 percent / methanol / 12 h / 20 °C
3.1: 39.6 percent / BCl3 / CH2Cl2 / 0.83 h / -78 °C
4.1: LDA / tetrahydrofuran / 0.25 h / -78 °C
4.2: 35 percent / tetrahydrofuran / -78 - 20 °C
5.1: BCl3; anisole / CH2Cl2 / 24 h / 0 °C
With
boron trichloride; methoxybenzene; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane;
1.1: Substitution / 2.1: Substitution / 3.1: Debenzylation / 4.1: Metallation / 4.2: Phosphorylation / 5.1: Debenzylation;
DOI:10.1021/jm990249v
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 64 percent / Ph3P; DEAD / tetrahydrofuran / 12 h / 20 °C
2.1: 88 percent / methanol / 12 h / 20 °C
3.1: 39.6 percent / BCl3 / CH2Cl2 / 0.83 h / -78 °C
4.1: LDA / tetrahydrofuran / 0.25 h / -78 °C
4.2: 35 percent / tetrahydrofuran / -78 - 20 °C
5.1: BCl3; anisole / CH2Cl2 / 24 h / 0 °C
With
boron trichloride; methoxybenzene; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane;
1.1: Substitution / 2.1: Substitution / 3.1: Debenzylation / 4.1: Metallation / 4.2: Phosphorylation / 5.1: Debenzylation;
DOI:10.1021/jm990249v
