APS-2-79 hydrochloride

Base Information

• Chemical Name: APS-2-79 hydrochloride
• CAS No.: 2002381-31-7
• Molecular Formula: C23H22ClN3O3
• Molecular Weight: 423.9
• Mol file: 2002381-31-7.mol

Synonyms:2002381-31-7;APS-2-79 hydrochloride;APS-2-79 HCl;APS-2-79 (hydrochloride);6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine hydrochloride;6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine;hydrochloride;APS279 hydrochloride;SCHEMBL18153640;BCP23567;CFD38131;EX-A2469;s8355;AKOS032944984;CCG-268926;CS-6151;HY-100627A;AC-36082;BS-15886;APS-2-79 hydrochloride, >=98% (HPLC);C73799;A902736;6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine HCl;6,7-Dimethoxy-N-(2-methyl-4-phenoxyphenyl)-4-quinazolinamine hydrochloride

Chemical Property of APS-2-79 hydrochloride

Chemical Property:

• Solubility.: Soluble in DMSO
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 423.1349693
• Heavy Atom Count: 30
• Complexity: 502

Purity/Quality:

97% ^*data from raw suppliers

APS-2-79hydrochloride >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1)OC2=CC=CC=C2)NC3=NC=NC4=CC(=C(C=C43)OC)OC.Cl
• Description: APS-2-79 is an inhibitor of MAPK signaling dependent on kinase suppressor of Ras (KSR). It inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 = 120 nM), stabilizes KSR2 in an inactive state, and reduces interactions between B-RAF and KSR2-MEK1 complexes. APS-2-79 (5 μM) inhibits KSR-stimulated phosphorylation of MEK and ERK in HEK293H cells. It enhances the efficacy of the MEK inhibitor trametinib , further reducing cell viability in HCT116 and A549 cell lines containing K-Ras mutations, but not B-RAF mutant SK-MEL-239 and A375 cell lines, when used at a concentration of 1 μM.
• Uses: APS-2-79 is a modulator of KSR-dependent MAPK signaling, antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation as well as the activation of KSR-bound MEK (mitogen-activated protein kinase).