2-Pyrrolidinecarbonitrile, 3,4-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methoxyphenyl)methyl] -5-oxo-, (2S,3S,4R)-

Base Information

Chemical Name:2-Pyrrolidinecarbonitrile, 3,4-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methoxyphenyl)methyl] -5-oxo-, (2S,3S,4R)-
CAS No.:370839-88-6
Molecular Formula:C25H42N2O4Si2
Molecular Weight:490.79
Hs Code.:
Mol file:370839-88-6.mol

Synonyms:

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Chemical Property of 2-Pyrrolidinecarbonitrile, 3,4-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methoxyphenyl)methyl] -5-oxo-, (2S,3S,4R)-

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Technology Process of 2-Pyrrolidinecarbonitrile, 3,4-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methoxyphenyl)methyl] -5-oxo-, (2S,3S,4R)-

There total 4 articles about 2-Pyrrolidinecarbonitrile, 3,4-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methoxyphenyl)methyl] -5-oxo-, (2S,3S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 2179-92-2
tri-n-butyltin cyanide

: 370839-87-5
(3R,4R)-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-acetoxy-1-(4-methoxybenzyl)-2-pyrrolidinone

: 370839-88-6
(3R,4S,5S)-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-cyano-1-(4-methoxybenzyl)-2-pyrrolidinone

: 370839-89-7
(3R,4S,5R)-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-cyano-1-(4-methoxybenzyl)-2-pyrrolidinone

Guidance literature:: With boron trifluoride diethyl etherate; In toluene; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(02)01218-8

Reference yield:

: (3R,4R)-3,4-bis(tert-butyldimethylsilyloxy)-1-(4-methoxybenzyl)pyrrolidine-2,5-dione

: 370839-88-6
(3R,4S,5S)-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-cyano-1-(4-methoxybenzyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium borohydride / methanol / 1 h / 0 °C

2: 14.0 g / pyridine / 20 °C

3: 10 percent / boron trifluoride etherate / toluene / 1 h / 20 °C

With pyridine; sodium tetrahydroborate; boron trifluoride diethyl etherate; In methanol; toluene;
DOI:10.1016/S0040-4020(02)01218-8

Reference yield:

: (3R,4R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-1-(4-methoxy-benzyl)-pyrrolidin-2-one

: 370839-88-6
(3R,4S,5S)-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-cyano-1-(4-methoxybenzyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 14.0 g / pyridine / 20 °C

2: 10 percent / boron trifluoride etherate / toluene / 1 h / 20 °C

With pyridine; boron trifluoride diethyl etherate; In toluene;
DOI:10.1016/S0040-4020(02)01218-8