Technology Process of 5,12-Dioxa-2,9-diazapentadec-14-enoic acid,
6-methyl-3-[(1S)-1-methylpropyl]-4,8,11-trioxo-10-(phenylmethyl)-7-[[(2,
2,2-trichloroethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester,
(3S,6R,7S,10S)-
There total 6 articles about 5,12-Dioxa-2,9-diazapentadec-14-enoic acid,
6-methyl-3-[(1S)-1-methylpropyl]-4,8,11-trioxo-10-(phenylmethyl)-7-[[(2,
2,2-trichloroethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester,
(3S,6R,7S,10S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran;
DOI:10.1016/S0040-4039(01)01136-4
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 100 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 20 h / 0 - 20 °C
2: 80 percent / N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-(dimethylamino)pyridine / tetrahydrofuran / 13 h / 0 - 20 °C
With
dmap; diethyl cyanophosphonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.12.009
- Guidance literature:
-
Multi-step reaction with 3 steps
1: HCl / ethyl acetate / 1.5 h
2: 100 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 20 h / 0 - 20 °C
3: 80 percent / N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-(dimethylamino)pyridine / tetrahydrofuran / 13 h / 0 - 20 °C
With
hydrogenchloride; dmap; diethyl cyanophosphonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.12.009
