Cyclobutanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1R,2R)- (9CI)

Base Information

Chemical Name:Cyclobutanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1R,2R)- (9CI)
CAS No.:371784-53-1
Molecular Formula:C8H12O3
Molecular Weight:156.181
Hs Code.:
Mol file:371784-53-1.mol

Synonyms:Acetic acid (1R,2R)-2-formyl-cyclobutylmethyl ester;

Suppliers and Price of Cyclobutanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1R,2R)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of Cyclobutanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1R,2R)- (9CI)

Chemical Property:

PSA：43.37000
LogP:0.77460

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclobutanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1R,2R)- (9CI)

There total 5 articles about Cyclobutanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1R,2R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 98516-06-4
((1R,2S)-2-(hydroxymethyl)cyclobutyl)methyl acetate

: 371784-53-1,701292-25-3,701292-26-4
((1R,2R)-2-formylcyclobutyl)methyl acetate

Guidance literature:: ((1R,2S)-2-(hydroxymethyl)cyclobutyl)methyl acetate; With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃;

With triethylamine; In dichloromethane; at 25 ℃; for 120h;

Reference yield:

: 4462-96-8
cis-1,2-cyclobutane dicarboxylic anhydride

: 371784-53-1,701292-25-3,701292-26-4
((1R,2R)-2-formylcyclobutyl)methyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 20 - 50 °C / Inert atmosphere

2.1: 50 °C

3.1: sodium citrate / water / 0.2 °C / pH Ca₅₄₅ / Enzymatic reaction

4.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 15 - 20 °C

4.2: 48 h / 1.8 - 20 °C

With lithium aluminium tetrahydride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; sodium citrate; In tetrahydrofuran; dichloromethane; water;