Technology Process of (4aR,7S)-4-Acetyl-6α,9α-epimino-4aβ,5,6,8,9,9aβ-hexahydro-1'-methylspiro[cyclohepta[c]pyran-7(1H),3'-[3H]indol]-2'(1'H)-one
There total 26 articles about (4aR,7S)-4-Acetyl-6α,9α-epimino-4aβ,5,6,8,9,9aβ-hexahydro-1'-methylspiro[cyclohepta[c]pyran-7(1H),3'-[3H]indol]-2'(1'H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine;
In
dichloromethane;
at 100 - 110 ℃;
for 60h;
Inert atmosphere;
Sealed tube;
DOI:10.1002/chem.201703572
- Guidance literature:
-
With
sodium hydroxide;
In
methanol;
at 20 ℃;
for 2h;
DOI:10.1021/ol020170b
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-phenylselenophthalimide; p-toluenesulfonic acid / CH2Cl2; methanol
1.2: 90 percent / sodium metaperiodate / tetrahydrofuran; H2O / 10 h / 0 °C
2.1: BH3*THF / 14 h / 0 °C
2.2: 85 percent / hydrogen peroxide / tetrahydrofuran
3.1: 80 percent / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH2Cl2 / 1.5 h
4.1: osmium tetraoxide; pyridine / tetrahydrofuran / 72 h / 20 °C
4.2: 81 percent / sodium hydrogen sulfite / tetrahydrofuran; H2O
5.1: hydrogen / Pd(OH)2/C / ethanol / 5 h / 20 °C
6.1: sodium hydroxide / methanol / 2 h / 20 °C
With
pyridine; sodium hydroxide; osmium(VIII) oxide; borane-THF; oxalyl dichloride; N-phenylselanylphthalimide; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
palladium dihydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
4.1: Swern oxidation;
DOI:10.1021/ol020170b
