5-Pyrimidinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(5,6-dihydroimidazo[1,2 -a]pyrazin-7(8H)-yl)-6-(4-hydroxy-1-piperidinyl)-, methyl ester

Base Information

• Chemical Name: 5-Pyrimidinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(5,6-dihydroimidazo[1,2 -a]pyrazin-7(8H)-yl)-6-(4-hydroxy-1-piperidinyl)-, methyl ester
• CAS No.: 372115-95-2
• Molecular Formula: C25H30ClN7O4
• Molecular Weight: 528.011
• Mol file: 372115-95-2.mol

Synonyms:

Chemical Property of 5-Pyrimidinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(5,6-dihydroimidazo[1,2 -a]pyrazin-7(8H)-yl)-6-(4-hydroxy-1-piperidinyl)-, methyl ester

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of 5-Pyrimidinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(5,6-dihydroimidazo[1,2 -a]pyrazin-7(8H)-yl)-6-(4-hydroxy-1-piperidinyl)-, methyl ester

There total 2 articles about 5-Pyrimidinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(5,6-dihydroimidazo[1,2 -a]pyrazin-7(8H)-yl)-6-(4-hydroxy-1-piperidinyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3-chloro-4-methoxybenzylamino)-5-methoxycarbonyl-6-(4-hydroxypiperidin-1-yl)-2-methylsulfinylpyrimidine (372118-34-8) + di-isopropyl ether (108-20-3) + tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazine (91476-80-1) → 4-(3-chloro-4-methoxybenzylamino)-5-methoxycarbonyl-6-(4-hydroxypiperidin-1-yl)-2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-7-yl)pyrimidine (372115-95-2)

Guidance literature:

With triethylamine; In methanol; N,N-dimethyl acetamide;

Reference yield:

4-benzylsulfinyl-5-methoxycarbonyl-6-(4-hydroxypiperidin-1-yl)-2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-7-yl)pyrimidine (372118-23-5) + N,N-dimethyl acetamide (127-19-5,116057-81-9) + (3-chloro-4-methoxyphenyl)methanamine (115514-77-7) → 4-(3-chloro-4-methoxybenzylamino)-5-methoxycarbonyl-6-(4-hydroxypiperidin-1-yl)-2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-7-yl)pyrimidine (372115-95-2)

Guidance literature:

With triethylamine;

upstream raw materials:

4-(3-chloro-4-methoxybenzylamino)-5-methoxycarbonyl-6-(4-hydroxypiperidin-1-yl)-2-methylsulfinylpyrimidine

di-isopropyl ether

tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazine

4-benzylsulfinyl-5-methoxycarbonyl-6-(4-hydroxypiperidin-1-yl)-2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-7-yl)pyrimidine

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