Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-bromo-6-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-3-methyl-1-(2-meth ylpropyl)-

Base Information

Chemical Name:Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-bromo-6-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-3-methyl-1-(2-meth ylpropyl)-
CAS No.:372162-71-5
Molecular Formula:C19H18BrF3N2O3S
Molecular Weight:491.329
Hs Code.:
Mol file:372162-71-5.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-bromo-6-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-3-methyl-1-(2-meth ylpropyl)-

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Technology Process of Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-bromo-6-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-3-methyl-1-(2-meth ylpropyl)-

There total 3 articles about Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-bromo-6-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-3-methyl-1-(2-meth ylpropyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 259862-18-5
6-bromo-3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 447-61-0
2-Trifluoromethylbenzaldehyde

: 372162-71-5
5-bromo-6-[hydroxy-[2-(trifluoromethyl)phenyl]methyl]-3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: 6-bromo-3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

2-Trifluoromethylbenzaldehyde; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2006.01.024

Reference yield:

: 216686-77-0
3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 447-61-0
2-Trifluoromethylbenzaldehyde

: 372162-71-5
5-bromo-6-[hydroxy-[2-(trifluoromethyl)phenyl]methyl]-3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With bromine; sodium thiosulfate; lithium diisopropyl amide; In tetrahydrofuran; tetrahydrofuran [THF]; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate;

Reference yield:

: 216686-77-0
3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 372162-71-5
5-bromo-6-[hydroxy-[2-(trifluoromethyl)phenyl]methyl]-3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / Br₂ / CH₂Cl₂

2.1: LDA / tetrahydrofuran / -78 °C

2.2: 71 percent / tetrahydrofuran

With bromine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2006.01.024