4-Hydroxy-3-iodobenzoic acid

Base Information

• Chemical Name: 4-Hydroxy-3-iodobenzoic acid
• CAS No.: 37470-46-5
• Molecular Formula: C7H5IO3
• Molecular Weight: 264.019
• Hs Code.: 2918290000
• Mol file: 37470-46-5.mol

Synonyms:2-Iodo-4-carboxyphenol;

Chemical Property of 4-Hydroxy-3-iodobenzoic acid

Chemical Property:

• Vapor Pressure: 6.86E-05mmHg at 25°C
• Melting Point: 172-175℃
• Refractive Index: 1.712
• Boiling Point: 330 °C at 760 mmHg
• Flash Point: 153.4 °C
• PSA: 57.53000
• Density: 2.155 g/cm³
• LogP: 1.69500
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-3-iodobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Hydroxy-3-iodobenzoic acidis used for enantioselective cross-electrophile Aryl-Alkenylation of unactivated alkenes.

Technology Process of 4-Hydroxy-3-iodobenzoic acid

There total 11 articles about 4-Hydroxy-3-iodobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

sodium thiosulfate + 4-hydroxy-benzoic acid (99-96-7) → 4-hydroxy-3-iodobenzoic acid (37470-46-5)

Guidance literature:

With sodium iodide; sodium perchlorate; sodium; In methanol;

Reference yield: 98.0%

4-hydroxy-benzoic acid (99-96-7) → 4-hydroxy-3-iodobenzoic acid (37470-46-5)

Guidance literature:

With trichloroisocyanuric acid; iodine; In dichloromethane; at 20 ℃;

DOI:10.1590/S0103-50532010000100002

Reference yield: 52.0%

3-amino-4-hydroxybenzoic acid (1571-72-8) → 4-hydroxy-3-iodobenzoic acid (37470-46-5)

Guidance literature:

3-amino-4-hydroxybenzoic acid; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

With potassium iodide; In water; at 0 - 70 ℃; for 1.5h;

upstream raw materials:

3,5-diiodo-4-hydroxybenzoic acid

4-hydroxy-benzoic acid

3-amino-4-hydroxybenzoic acid

water

Downstream raw materials:

4-hydroxy-3-iodo-benzoic acid ethyl ester

3,4-Dihydroxybenzoic acid

3-iodo-4-hydroxy-5-nitrobenzoic acid

3,5-diiodo-4-hydroxybenzoic acid