Technology Process of Ethanethioic acid,
S-[6-[4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-2,5-dimethoxy
phenyl]hexyl] ester
There total 10 articles about Ethanethioic acid,
S-[6-[4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-2,5-dimethoxy
phenyl]hexyl] ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-(2,5-dimethoxy-4-(2-[N,N-phthalimido]propyl)phenyl)hexyl bromide;
With
4 A molecular sieve;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
potassium thioacetate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 18h;
DOI:10.3390/71100777
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: aluminum chloride / nitrobenzene / 23 h / 0 - 20 °C
2.1: 11.4 g / 3 M NaOH
3.1: 94 percent / conc. H2SO4 / 18 h / Heating
4.1: 33 percent / zinc amalgam; conc. HCl / methanol / 3 h / Heating
5.1: phosphorus oxychloride / 2 h / Heating
5.2: 35 percent / H2O / 18 h / 20 °C
6.1: 35 percent / ammonium acetate / acetic acid / 4 h / Heating
7.1: 66 percent / lithium aluminum hydride / diethyl ether / 48 h / Heating
8.1: 95 percent / sodium bicarbonate / tetrahydrofuran; H2O / 18 h / 20 °C
9.1: 27 percent / triphenylphosphine; N-bromosuccinimide / CH2Cl2 / 0 - 22 °C
10.1: molecular sieves 4 Angstroem / dimethylformamide / 1 h / 20 °C
10.2: 82 percent / dimethylformamide / 18 h / 20 °C
With
ammonium acetate; hydrogenchloride; sodium hydroxide; amalgamated zinc; N-Bromosuccinimide; lithium aluminium tetrahydride; aluminium trichloride; 4 A molecular sieve; sulfuric acid; sodium hydrogencarbonate; triphenylphosphine; trichlorophosphate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetic acid; nitrobenzene; N,N-dimethyl-formamide;
1.1: Friedel-Crafts acylation / 5.1: Vilsmeier-Haack formylation;
DOI:10.3390/71100777
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: aluminum chloride / nitrobenzene / 23 h / 0 - 20 °C
2.1: 11.4 g / 3 M NaOH
3.1: 94 percent / conc. H2SO4 / 18 h / Heating
4.1: 33 percent / zinc amalgam; conc. HCl / methanol / 3 h / Heating
5.1: phosphorus oxychloride / 2 h / Heating
5.2: 35 percent / H2O / 18 h / 20 °C
6.1: 35 percent / ammonium acetate / acetic acid / 4 h / Heating
7.1: 66 percent / lithium aluminum hydride / diethyl ether / 48 h / Heating
8.1: 95 percent / sodium bicarbonate / tetrahydrofuran; H2O / 18 h / 20 °C
9.1: 27 percent / triphenylphosphine; N-bromosuccinimide / CH2Cl2 / 0 - 22 °C
10.1: molecular sieves 4 Angstroem / dimethylformamide / 1 h / 20 °C
10.2: 82 percent / dimethylformamide / 18 h / 20 °C
With
ammonium acetate; hydrogenchloride; sodium hydroxide; amalgamated zinc; N-Bromosuccinimide; lithium aluminium tetrahydride; aluminium trichloride; 4 A molecular sieve; sulfuric acid; sodium hydrogencarbonate; triphenylphosphine; trichlorophosphate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetic acid; nitrobenzene; N,N-dimethyl-formamide;
1.1: Friedel-Crafts acylation / 5.1: Vilsmeier-Haack formylation;
DOI:10.3390/71100777
![6-(2,5-dimethoxy-4-(2-[N,N-phthalimido]propyl)phenyl)hexyl bromide](/Databaselist/images/loading.webp)
