6-CHLORO-7H-PURIN-8(9H)-ONE

Base Information

• Chemical Name: 6-CHLORO-7H-PURIN-8(9H)-ONE
• CAS No.: 37527-48-3
• Molecular Formula: C5H3ClN4O
• Molecular Weight: 170.558
• Hs Code.: 2933990090
• Mol file: 37527-48-3.mol

Synonyms:6-Chloro-7,9-dihydro-purin-8-one;6-Chlor-7,9-dihydro-purin-8-on;6-CHLORO-8,9-DIHYDRO-7H-PURIN-8-ONE;6-chloro-7H-purin-8(9H)-one;

Chemical Property of 6-CHLORO-7H-PURIN-8(9H)-ONE

Chemical Property:

• PKA: 6.42±0.40(Predicted)
• PSA: 66.18000
• Density: 2.09±0.1 g/cm3(Predicted)
• LogP: -1.20850

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-7H-purin-8(9H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Chloro-7H-purin-8(9H)-one is a useful intermediate in the preparation of the metabolites of tri-O-acetyl-N6-(hydroxyphenyl)adenosine.

Technology Process of 6-CHLORO-7H-PURIN-8(9H)-ONE

There total 6 articles about 6-CHLORO-7H-PURIN-8(9H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-chloro-4,5-diaminopyrimidine (4316-98-7) + 1,1'-carbonyldiimidazole (530-62-1) → 6-chloro-7H-purin-8(9H)-one (37527-48-3)

Guidance literature:

In 1,4-dioxane; for 0.833333h; Reflux; Inert atmosphere;

Reference yield: 78.0%

6-chloro-4,5-diaminopyrimidine (4316-98-7) + di(succinimido) carbonate (74124-79-1) → 6-chloro-7H-purin-8(9H)-one (37527-48-3)

Guidance literature:

In acetonitrile; for 16h; Heating / reflux;

Reference yield:

6-chloro-4,5-diaminopyrimidine (4316-98-7) + 1,1'-carbonyldiimidazole (530-62-1) → 8-hydroxy-6-chloroadenine (37527-48-3)

Guidance literature:

In 1,4-dioxane; for 6h; Reflux;

DOI:10.3390/molecules21010008

upstream raw materials:

6,8-dichloro-7(9)H-purine

6-chloro-4,5-diaminopyrimidine

1,1'-carbonyldiimidazole

diceto-6,8 purine

Downstream raw materials:

6-(4-phenylacetylpiperidin-1-yl)-7,9-dihydropurin-8-one

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