XAP044

Base Information

• Chemical Name: XAP044
• CAS No.: 196928-50-4
• Molecular Formula: C15H9IO4
• Molecular Weight: 380.13
• Mol file: 196928-50-4.mol

Synonyms:7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one;XAP044;7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one;4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-iodophenoxy)-;XAP-044,mGlu7,XAP044,neurotransmission,brain exposure,CNS,inhibit,mGluR,antidepressant,Metabotropic glutamate receptors,wide spectrum,anti-stress,Inhibitor,anxiolytic-like,XAP 044

Chemical Property of XAP044

Chemical Property:

• Boiling Point: 485.7±45.0 °C
• PKA: 6.70±0.20(Predicted)
• Density: 1.853±0.06 g/cm3
• Solubility.: ≤10mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

XAP 044 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

• Description: XAP044 is an antagonist of the metabotropic glutamate (mGlu) receptor 7 (mGluR7), inhibiting lateral amygdala long term potentiation in brain slices from wild-type mice with an IC50 value of 88 nM. This effect is absent in mGluR7-deficient mice. XAP044 demonstrates good brain penetrance, producing wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral tests.
• Uses: XAP 044 is a potent mGlu7 antagonist used in the treatment of anxiety and depression in mice (1,2). Applications towards stress, autism and drug abuse are also potential uses.

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