4-(2-Methoxy-benzyl)-piperidine hydrochloride

Base Information

• Chemical Name: 4-(2-Methoxy-benzyl)-piperidine hydrochloride
• CAS No.: 37581-34-3
• Molecular Formula: C13H19NO.ClH
• Molecular Weight: 241.75700
• Hs Code.: 2933399090
• European Community (EC) Number: 872-706-4
• DSSTox Substance ID: DTXSID60588778
• Mol file: 37581-34-3.mol

Synonyms:37581-34-3;4-(2-Methoxy-benzyl)-piperidine hydrochloride;4-(2-Methoxybenzyl)piperidine hydrochloride;4-[(2-methoxyphenyl)methyl]piperidine hydrochloride;4-[(2-methoxyphenyl)methyl]piperidine;hydrochloride;SCHEMBL21632839;DTXSID60588778;4-(2-Methoxybenzyl)piperidine HCl;MFCD08437508;AKOS027385246;AB45042;MCULE-5061293068;BS-16692;4-(2-Methoxybenzyl)piperidinehydrochloride;CS-0163318;EN300-64876;D83316;Z1262327435;4-[(2-Methoxyphenyl)methyl]piperidine--hydrogen chloride (1/1)

Chemical Property of 4-(2-Methoxy-benzyl)-piperidine hydrochloride

Chemical Property:

• Vapor Pressure: 0.000532mmHg at 25°C
• Boiling Point: 312.3oC at 760 mmHg
• Flash Point: 128.4oC
• PSA: 21.26000
• LogP: 3.36810
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 241.1233420
• Heavy Atom Count: 16
• Complexity: 177

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Methoxybenzyl)piperidine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1CC2CCNCC2.Cl

Technology Process of 4-(2-Methoxy-benzyl)-piperidine hydrochloride

There total 4 articles about 4-(2-Methoxy-benzyl)-piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(2-methoxyphenyl)(pyridine-4-yl)methanone (22631-61-4) → 4-[(2-methoxyphenyl)methyl]piperidine hydrochloride (37581-34-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; 1,2-dichloro-ethane; at 45 ℃; for 4h; chemoselective reaction;

DOI:10.1016/j.tet.2013.12.017

Reference yield: 91.0%

α-(2-methoxyphenyl)-4-pyridinemethanol (130406-94-9) → 4-[(2-methoxyphenyl)methyl]piperidine hydrochloride (37581-34-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; at 75 ℃; under 750.075 Torr;

DOI:10.1002/ejoc.200400215

Reference yield:

pyridine-4-carbaldehyde (872-85-5) → 4-[(2-methoxyphenyl)methyl]piperidine hydrochloride (37581-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / tetrahydrofuran / 10 h / 20 °C

2: 91 percent / H₂ / Pd/C / acetic acid / 75 °C / 750.08 Torr

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; acetic acid;

DOI:10.1002/ejoc.200400215

upstream raw materials:

α-(2-methoxyphenyl)-4-pyridinemethanol

pyridine-4-carbaldehyde

2-methoxyphenylmagnesium bromide

(2-methoxyphenyl)(pyridine-4-yl)methanone

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