N-(4-octylphenyl)acetamide

Base Information

• Chemical Name: N-(4-octylphenyl)acetamide
• CAS No.: 37593-11-6
• Molecular Formula: C16H25NO
• Molecular Weight: 247.381
• DSSTox Substance ID: DTXSID501311510
• Nikkaji Number: J1.415.088I
• Mol file: 37593-11-6.mol

Synonyms:N-(4-octylphenyl)acetamide;37593-11-6;SCHEMBL11297385;DTXSID501311510

Chemical Property of N-(4-octylphenyl)acetamide

Chemical Property:

• XLogP3: 5.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 8
• Exact Mass: 247.193614421
• Heavy Atom Count: 18
• Complexity: 219

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCCCCCCCC1=CC=C(C=C1)NC(=O)C

Technology Process of N-(4-octylphenyl)acetamide

There total 6 articles about N-(4-octylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-octylaniline (16245-79-7) + acetic anhydride (108-24-7) → N-(4-octylphenyl)acetamide (37593-11-6)

Guidance literature:

at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2004.07.030

Reference yield: 93.0%

oct-1-ene (111-66-0,25068-25-1) + 4-bromoacetanilide (103-88-8) → N-(4-octylphenyl)acetamide (37593-11-6)

Guidance literature:

oct-1-ene; With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; at 20 ℃; for 17h;

4-bromoacetanilide; With potassium phosphate; 2H⁽¹⁺⁾*Cl₄Pd^(2-)*2H₃N; poly[N-isopropylacrylamide-co-diphenyl(4'-styryl)phosphine]; In tetrahydrofuran; 1,4-dioxane; at 100 ℃; for 10h;

DOI:10.1021/jo034354v

Reference yield: 87.0%

1-bromo-octane (111-83-1) + 4-bromoacetanilide (103-88-8) → N-(4-octylphenyl)acetamide (37593-11-6)

Guidance literature:

With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; [2,2]bipyridinyl; sodium iodide; zinc; at 60 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tet.2014.10.061

upstream raw materials:

4-octylaniline

acetic anhydride

oct-1-ene

4-bromoacetanilide

Downstream raw materials:

n-octyl-4 nitro-2 acetanilide

diamino-1,2 n-octyl-4 benzene

n-octyl-4 nitro-2 aniline

[2-benzyloxy-1-(6-octyl-1H-benzoimidazol-2-yl)-propyl]-carbamic acid tert-butyl ester