5-(4-Methoxyphenyl)-3-(4-methylphenyl)-1,2-oxazole

Base Information

• Chemical Name: 5-(4-Methoxyphenyl)-3-(4-methylphenyl)-1,2-oxazole
• CAS No.: 37613-33-5
• Molecular Formula: C17H15NO2
• Molecular Weight: 265.312
• DSSTox Substance ID: DTXSID80495899
• Wikidata: Q82344318
• Mol file: 37613-33-5.mol

Synonyms:37613-33-5;5-(4-Methoxyphenyl)-3-(p-tolyl)isoxazole;5-(4-methoxyphenyl)-3-(4-methylphenyl)-1,2-oxazole;SCHEMBL17084390;DTXSID80495899

Chemical Property of 5-(4-Methoxyphenyl)-3-(4-methylphenyl)-1,2-oxazole

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 265.110278721
• Heavy Atom Count: 20
• Complexity: 293

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=NOC(=C2)C3=CC=C(C=C3)OC

Technology Process of 5-(4-Methoxyphenyl)-3-(4-methylphenyl)-1,2-oxazole

There total 11 articles about 5-(4-Methoxyphenyl)-3-(4-methylphenyl)-1,2-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

→ 5-(4-methoxyphenyl)-3-(p-tolyl)isoxazole (37613-33-5)

Guidance literature:

With copper(I) oxide; triethylamine; In ethanol; at 60 ℃; Inert atmosphere;

Reference yield: 82.0%

3-(4-methoxyphenyl)-1-p-tolylprop-2-en-1-one (6552-66-5,50990-40-4,102692-51-3) → 5-(4-methoxyphenyl)-3-(p-tolyl)isoxazole (37613-33-5)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In dimethyl sulfoxide; at 100 ℃; for 8h;

DOI:10.3184/174751916X14744677622496

Reference yield: 73.0%

3-(4-methylphenyl)-5-(4-methoxyphenyl)-4,5-dihydroisoxazole (51250-75-0) → 5-(4-methoxyphenyl)-3-(p-tolyl)isoxazole (37613-33-5)

Guidance literature:

With manganese(IV) oxide; In benzene; for 2h; Heating;

upstream raw materials:

1-(4-methoxy-phenyl)-3-p-tolyl-propane-1,3-dione

4-methylacethophenone oxime

4-methoxybenzonitrile

3-(4-methylphenyl)-5-(4-methoxyphenyl)-4,5-dihydroisoxazole

Downstream raw materials:

2-(4-{4-[5-(4-methoxy-phenyl)-isoxazol-3-yl]-styryl}-phenyl)-4-phenyl-2H-[1,2,3]triazole

4-(4-{4-[5-(4-methoxy-phenyl)-isoxazol-3-yl]-styryl}-phenyl)-2-phenyl-2H-[1,2,3]triazole

5-(4-methoxy-phenyl)-3-{4-[4-(3-phenyl-pyrazol-1-yl)-styryl]-phenyl}-isoxazole

3-{4-[4-(2,5-diphenyl-2H-pyrazol-3-yl)-styryl]-phenyl}-5-(4-methoxy-phenyl)-isoxazole