2,2,4,4-Tetramethylvaleramide

Base Information

• Chemical Name: 2,2,4,4-Tetramethylvaleramide
• CAS No.: 32905-64-9
• Molecular Formula: C9H19NO
• Molecular Weight: 0
• Mol file: 32905-64-9.mol

Synonyms:

Chemical Property of 2,2,4,4-Tetramethylvaleramide

Chemical Property:

• Vapor Pressure: 0.0114mmHg at 25°C
• Boiling Point: 261.6°C at 760 mmHg
• Flash Point: 112°C
• Density: 0.883g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,4,4-Tetramethylvaleramide

There total 4 articles about 2,2,4,4-Tetramethylvaleramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,4,4-tetramethylpentanoic acid (3302-12-3) → 2,2,4,4-Tetramethylpentansaeureamid (32905-64-9)

Guidance literature:

With thionyl chloride; und mit wasserfreiem NH₃ in Aether;

DOI:10.1021/ja01856a601

Reference yield:

2,2,4,4-tetramethyl-pentanoyl chloride (32905-63-8) → 2,2,4,4-Tetramethylpentansaeureamid (32905-64-9)

Guidance literature:

With ammonium hydroxide;

Reference yield:

2-chloro-2,4,4-trimethylpentane (6111-88-2) → 2,2,4,4-Tetramethylpentansaeureamid (32905-64-9)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) EtMgBr, Et₂O, (ii) /BRN= 1900390/

2: SOCl₂ / 3 h / Heating

3: aq. NH₃

With ammonium hydroxide; thionyl chloride;

upstream raw materials:

2,2,4,4-tetramethylpentanoic acid

2,2,4,4-tetramethyl-pentanoyl chloride

2-chloro-2,4,4-trimethylpentane

Downstream raw materials:

2,2,4,4-Tetramethyl-pentanoic acid (2,2,2-trichloro-1-hydroxy-ethyl)-amide