(E)-4-fluorobut-2-enoic Acid

Base Information

Chemical Name:(E)-4-fluorobut-2-enoic Acid
CAS No.:37759-72-1
Molecular Formula:C4H5FO2
Molecular Weight:104.081
Hs Code.:
European Community (EC) Number:843-089-9
Nikkaji Number:J3.371.200F
Wikidata:Q76326377
Mol file:37759-72-1.mol

Synonyms:(E)-4-fluorobut-2-enoic Acid;37759-72-1;4-fluorobut-2-enoic acid;(2E)-4-fluorobut-2-enoic acid, E;4485-57-8;4-fluorocrotonic acid;starbld0032722;4-Fluoro-2-butenoic acid;SCHEMBL24950;SCHEMBL24951;(2E)-4-fluorobut-2-enoic acid;VLPAEVHYNQOJRT-OWOJBTEDSA-N;AKOS006376696;AT12709;CS-0146915;EN300-149758;EN300-1574386

Suppliers and Price of (E)-4-fluorobut-2-enoic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of (E)-4-fluorobut-2-enoic Acid

Chemical Property:

XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:104.02735756
Heavy Atom Count:7
Complexity:87.7

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C(C=CC(=O)O)F
Isomeric SMILES:C(/C=C/C(=O)O)F

Technology Process of (E)-4-fluorobut-2-enoic Acid

There total 1 articles about (E)-4-fluorobut-2-enoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 87121-06-0
1,1-bis(trimethylsilyloxy)-buta-1,3-diene

: 37759-72-1
(E)-4-fluorobut-2-enoic acid

Guidance literature:: With fluorine; In trichlorofluoromethane; at -78 ℃;
DOI:10.1016/S0022-1139(00)80219-5

Reference yield: 33.0%

: 37759-72-1
(E)-4-fluorobut-2-enoic acid

: 1609468-26-9
(R)-5-amino-3-(4-(2,4-difluorophenoxy)phenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide

: 1609467-20-0
5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-{(3R)-1-[(2E)-4-fluorobut-2-enoyl]piperidin-3-yl}-1H-pyrazole-4-carboxamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;
DOI:10.1021/acsmedchemlett.8b00461

Reference yield:

: 37759-72-1
(E)-4-fluorobut-2-enoic acid

: 1609468-24-7
(R)-5-amino-3-(4-(4-chlorophenoxy)phenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide

: 1609467-07-3
5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-{(3R)-1-[(2E)-4-fluorobut-2-enoyl]piperidin-3-yl}-1H-pyrazole-4-carboxamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;