ethyl 4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Base Information

• Chemical Name: ethyl 4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
• CAS No.: 37801-47-1
• Molecular Formula: C₁₂H₁₄ClN₃O₂
• Molecular Weight: 267.715
• Hs Code.: 2933998090
• DSSTox Substance ID: DTXSID301331578
• Wikidata: Q107856135
• ChEMBL ID: CHEMBL1481872
• Mol file: 37801-47-1.mol

Synonyms:ethyl 4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate;37801-47-1;ethyl 4-chloro-1-ethyl-3-methylpyrazolo[3,4-b]pyridine-5-carboxylate;Ethyl 4-chloro-1-ethyl-3-methyl-1H-pyrazolo-[3,4-b]pyridine-5-carboxylate;Bionet2_001411;MLS000696523;SCHEMBL583300;CHEMBL1481872;DTXSID301331578;HMS1368A03;HMS2721C16;AMY35251;MFCD04124526;AKOS005081546;PB30812;SMR000336635;CS-0049468;P10298;SR-01000307088;12W-0020;SR-01000307088-1;Ethyl4-chloro-1-ethyl-3-methyl-1H-pyrazolo-[3,4-b]pyridine-5-carboxylate;1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid,4-chloro-1-ethyl-3-methyl-, ethyl ester;4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]-pyridine-5-carboxylic acid ethyl ester;4-Chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester;4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester

Chemical Property of ethyl 4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Chemical Property:

• PSA: 57.01000
• LogP: 2.58970
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 267.0774544
• Heavy Atom Count: 18
• Complexity: 316

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-chloro-1-ethyl-3-methyl-1H-pyrazolo-[3,4-b]pyridine-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1C2=NC=C(C(=C2C(=N1)C)Cl)C(=O)OCC

Technology Process of ethyl 4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

There total 5 articles about ethyl 4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethyl-3-methyl-4-oxo-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (34970-34-8) → 4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (37801-47-1)

Guidance literature:

With trichlorophosphate; In water;

Reference yield:

(2-ethyl-5-methyl-2H-pyrazol-3-ylaminomethylene)-malonic acid diethyl ester (26824-00-0) → 4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (37801-47-1)

Guidance literature:

With trichlorophosphate; at 120 ℃;

DOI:10.1248/cpb.52.1098

Reference yield:

1-ethyl-3-methyl-1H-pyrazol-5-amine (3524-33-2) → 4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (37801-47-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 120 °C

2: POCl₃ / 120 °C

With trichlorophosphate; 1: Michael addition;

DOI:10.1248/cpb.52.1098

upstream raw materials:

(2-ethyl-5-methyl-2H-pyrazol-3-ylaminomethylene)-malonic acid diethyl ester

1-ethyl-3-methyl-1H-pyrazol-5-amine

1-ethyl-3-methyl-4-oxo-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

diethyl 2-ethoxymethylenemalonate

Downstream raw materials:

4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 37801-47-1 ETHYL 4-CHLORO-1-ETHYL-3-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE

Send

Send

Metric Ton KG G Pound L ML

Send

Send