ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE
• CAS No.: 37945-37-2
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.26900
• Hs Code.: 2933990090
• Mol file: 37945-37-2.mol

Synonyms:ethyl 3-methyl-4,5,6,7-tetrahydroindole-2-carboxylate;3-Methyl-4,5,6,7-tetrahydro-indol-2-carbonsaeure-aethylester;3-methyl-4,5,6,7-tetrahydro-indole-2-carboxylic acid ethyl ester;2-Carbethoxy-3-methyl-4,5,6,7-tetrahydroindole;

Chemical Property of ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE

Chemical Property:

• PSA: 42.09000
• LogP: 2.37860

Purity/Quality:

98%min ^*data from raw suppliers

ethyl3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE

There total 14 articles about ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.4%

4-<5-(ethoxycarbonyl)-2-iodo-4-methylpyrrol-3-yl>-1-iodobutane (98977-12-9) → ethyl 3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate (37945-37-2) + 4-<5-(ethoxycarbonyl)-4-methylpyrrol-3-yl>-1-iodobutane (98977-14-1)

Guidance literature:

With hydrogen iodide; In ethanol; for 1h;

DOI:10.1021/jo00233a011

Reference yield: 42.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 3-oxo-2-(phenylhydrazono)butyric acid ethyl ester (10475-63-5) → ethyl 3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate (37945-37-2)

Guidance literature:

With sodium acetate; acetic acid; zinc; for 1h; Heating;

DOI:10.1021/jo00044a012

Reference yield:

4-<5-(ethoxycarbonyl)-2-carboxy-4-methylpyrrol-3-yl>-1-iodobutane (98977-10-7) → ethyl 3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate (37945-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaHCO₃, 2.) KI/I₂ / 1.) water, MeCl₂, reflux, 2.) water, MeCl₂, reflux, 30 min

2: HI / ethanol / 1 h

With hydrogen iodide; iodine; sodium hydrogencarbonate; potassium iodide; In ethanol;

DOI:10.1021/jo00233a011

upstream raw materials:

cyclohexanone

ethyl 2-hydroxyimino-3-oxobutanoate

aminomalonic acid diethyl ester

2-acetylcyclohexanone

Downstream raw materials:

1-(3-Benzyloxy-4-methyl-2-nitro-benzoyl)-3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylic acid ethyl ester

3-Methyl-4,5,6,7-tetrahydro-1H-indole

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