trans-2-(3,4-Dichlorophenyl)-N-methyl-N-(2-pyrrolidinocyclohexyl)acetamide hydrochloride

Base Information

Chemical Name:trans-2-(3,4-Dichlorophenyl)-N-methyl-N-(2-pyrrolidinocyclohexyl)acetamide hydrochloride
CAS No.:67197-96-0
Molecular Formula:C₁₉H₂₆Cl₂N₂O*ClH
Molecular Weight:405.795
Hs Code.:

Synonyms:

Suppliers and Price of trans-2-(3,4-Dichlorophenyl)-N-methyl-N-(2-pyrrolidinocyclohexyl)acetamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of trans-2-(3,4-Dichlorophenyl)-N-methyl-N-(2-pyrrolidinocyclohexyl)acetamide hydrochloride

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of trans-2-(3,4-Dichlorophenyl)-N-methyl-N-(2-pyrrolidinocyclohexyl)acetamide hydrochloride

There total 5 articles about trans-2-(3,4-Dichlorophenyl)-N-methyl-N-(2-pyrrolidinocyclohexyl)acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69420-67-3
(+/-)-trans-[2-(pyrrolidinyl)]cyclohexanol

: 67197-96-0,74512-83-7,109620-49-7,114358-63-3,114528-79-9,114528-81-3,121843-55-8
U 50488 hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

2: diethyl ether; water / 18 h / 10 - 20 °C / Inert atmosphere; Cooling with ice

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: hydrogenchloride / diethyl ether; ethyl acetate / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100278

Reference yield:

: 67198-34-9,67198-53-2,67347-43-7,99239-39-1,116301-06-5,121843-49-0,121843-50-3,121843-51-4,142434-12-6
trans-(+/-)-N-methyl-2-(pyrrolidin-1-yl)cyclohexanamine

: 67197-96-0,74512-83-7,109620-49-7,114358-63-3,114528-79-9,114528-81-3,121843-55-8
U 50488 hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: hydrogenchloride / diethyl ether; ethyl acetate / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100278

Reference yield:

: 286-20-4
cyclohexane-1,2-epoxide

: 67197-96-0,74512-83-7,109620-49-7,114358-63-3,114528-79-9,114528-81-3,121843-55-8
U 50488 hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 18 h / 80 °C / Inert atmosphere

2: triethylamine / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

3: diethyl ether; water / 18 h / 10 - 20 °C / Inert atmosphere; Cooling with ice

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: hydrogenchloride / diethyl ether; ethyl acetate / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100278