Imidazo[1,2-a]pyrimidine

Base Information

• Chemical Name: Imidazo[1,2-a]pyrimidine
• CAS No.: 274-95-3
• Molecular Formula: C6H5N3
• Molecular Weight: 119.126
• Hs Code.: 2933990090
• Mol file: 274-95-3.mol

Synonyms:1,3a,7-Triazaindene;1,8-Diazaindolizine;3,4-Diazaindolizine;8-Azapyrimidazole;

Chemical Property of Imidazo[1,2-a]pyrimidine

Chemical Property:

• Melting Point: 127-129 °C
• Refractive Index: 1.689
• PKA: 5.50±0.30(Predicted)
• PSA: 30.19000
• Density: 1.294 g/cm³
• LogP: 0.72930
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

Imidazo[1,2-a]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-a]pyrimidine

There total 5 articles about Imidazo[1,2-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-aminopyrimidine (109-12-6) + 2-chloroethanal (107-20-0) → imidazo[1,2-a]pyrimidine (274-95-3)

Guidance literature:

In ethanol; Reflux;

DOI:10.1021/acs.jmedchem.0c02064

Reference yield: 66.0%

malondialdehyde bis(diethyl acetal) (122-31-6) + 2-aminoimidazole hemisulfate (1450-93-7,36946-29-9,42383-61-9) → imidazo[1,2-a]pyrimidine (274-95-3)

Guidance literature:

In ethanol; acetic acid; for 5h; Heating;

Reference yield: 66.0%

(E)-3-ethoxyacrylaldehyde (764-63-6) + 2-aminoimidazole hemisulfate (1450-93-7,36946-29-9,42383-61-9) → imidazo[1,2-a]pyrimidine (274-95-3)

Guidance literature:

In ethanol; acetic acid; for 5h; Heating;

upstream raw materials:

2-aminopyrimidine

2-chloroethanal

malondialdehyde bis(diethyl acetal)

2-aminoimidazole hemisulfate

Downstream raw materials:

3-formylimidazo<1,2-a>pyrimidine

3-chloroimidazolo[1,2-a]pyrimidine

5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine

3-nitroimidazo<1,2-a>pyridimine

Refernces

• 1、 Juillet, Charlotte,Ermolenko, Ludmila,Boyarskaya, Dina,Baratte, Blandine,Josselin, Béatrice,Nedev, Hristo,Bach, Stéphane,Iorga, Bogdan I.,Bignon, Jér?me,Ruchaud, Sandrine,Al-Mourabit, Ali. "From Synthetic Simplified Marine Metabolite Analogues to New Selective Allosteric Inhibitor of Aurora B Kinase". . p. 1197 - 1219. Retrieved 2021/02/05.
• 2、 Loeber, Stefan,Huebner, Harald,Gmeiner, Peter. "Azaindole Derivatives with High Affinity for the Dopamine D4 Receptor: Synthesis, Ligand Binding Studies and Comparison of Molecular Electrostatic Potential Maps". . p. 97 - 102. Retrieved 2007/10/03.