N-Hydroxy-N-(naphthalen-1-yl)acetamide

Base Information

• Chemical Name: N-Hydroxy-N-(naphthalen-1-yl)acetamide
• CAS No.: 38105-20-3
• Molecular Formula: C12H11NO2
• Molecular Weight: 201.225
• ChEMBL ID: CHEMBL314719
• DSSTox Substance ID: DTXSID60500930
• Nikkaji Number: J2.457.595K
• Wikidata: Q82352973
• Mol file: 38105-20-3.mol

Synonyms:38105-20-3;N-Hydroxy-N-(naphthalen-1-yl)acetamide;CHEMBL314719;SCHEMBL10958989;DTXSID60500930

Chemical Property of N-Hydroxy-N-(naphthalen-1-yl)acetamide

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 201.078978594
• Heavy Atom Count: 15
• Complexity: 242

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)N(C1=CC=CC2=CC=CC=C21)O

Technology Process of N-Hydroxy-N-(naphthalen-1-yl)acetamide

There total 1 articles about N-Hydroxy-N-(naphthalen-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

N-Acetoxy-1-N-acetylaminonaphtalene (38105-25-8) → N-hydroxy-N-(naphthalene-1-yl)acetamide (38105-20-3) + 1-acetamidonaphthalen-2-yl acetate (98728-70-2) + N-(4-hydroxy-1-naphthalenyl)acetamide (85-12-1) + 4-acetoxy-1-(acetylamino)naphthalene (98728-71-3) + 1-acetylamino-naphthalen-2-ol (117-93-1)

Guidance literature:

With water; In acetone; at 40 ℃; Product distribution; Rate constant; solvolysis at pH = 5-10 values and an ionic strength of 0.25 M (maintained by NaClO₄);

DOI:10.1039/c39850000555

Reference yield: 62.0%

N-hydroxy-N-(naphthalene-1-yl)acetamide (38105-20-3) → N-(4-hydroxy-1-naphthalenyl)acetamide (85-12-1)

Guidance literature:

With Phenylselenyl bromide; In 1,4-dioxane; at 23 ℃; for 12h;

DOI:10.1002/anie.202100801

upstream raw materials:

N-Acetoxy-1-N-acetylaminonaphtalene

Downstream raw materials:

N-(4-hydroxy-1-naphthalenyl)acetamide

Refernces