5-FLUORO-2-PHENYLSULFONYLNITROBENZENE

Base Information

• Chemical Name: 5-FLUORO-2-PHENYLSULFONYLNITROBENZENE
• CAS No.: 381666-56-4
• Molecular Formula: C12H8FNO4S
• Molecular Weight: 281.264
• Mol file: 381666-56-4.mol

Synonyms:4-fluoro-2-nitro-1-(phenylsulfonyl)-benzene;

Chemical Property of 5-FLUORO-2-PHENYLSULFONYLNITROBENZENE

Chemical Property:

• Melting Point: 127 - 129 °C
• PSA: 88.34000
• LogP: 4.17070

Purity/Quality:

98%min ^*data from raw suppliers

5-Fluoro-2-phenylsulfonylnitrobenzene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 5-FLUORO-2-PHENYLSULFONYLNITROBENZENE

There total 2 articles about 5-FLUORO-2-PHENYLSULFONYLNITROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

(4-fluoro-2-nitrophenyl)(phenyl)sulfane (33358-34-8) → 4-fluoro-2-nitro-1-(phenylsulfonyl)-benzene (381666-56-4)

Guidance literature:

With dihydrogen peroxide;

DOI:10.1021/cb500789h

Reference yield:

1-chloro-4-fluoro-2-nitrobenzene (345-17-5) + thiophenol (108-98-5) → 4-fluoro-2-nitro-1-(phenylsulfonyl)-benzene (381666-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water

2: dihydrogen peroxide

With dihydrogen peroxide; sodium hydroxide; In ethanol; water;

DOI:10.1021/cb500789h

Reference yield:

piperazine (110-85-0) + 4-fluoro-2-nitro-1-(phenylsulfonyl)-benzene (381666-56-4) → 1-[3-nitro-4-(phenylsulfonyl)-phenyl]piperazine (381666-57-5)

Guidance literature:

With potassium carbonate; In dichloromethane; water; acetonitrile;

upstream raw materials:

(4-fluoro-2-nitrophenyl)(phenyl)sulfane

1-chloro-4-fluoro-2-nitrobenzene

thiophenol

Downstream raw materials:

1-[3-nitro-4-(phenylsulfonyl)-phenyl]piperazine