3-Oxazolidinecarboxamide, N-[3-[4-[3-(acetylamino)phenyl]-1-piperidinyl]propyl]-4-(3,5-difluorophen yl)-2-oxo-, (4S)-

Base Information

• Chemical Name: 3-Oxazolidinecarboxamide, N-[3-[4-[3-(acetylamino)phenyl]-1-piperidinyl]propyl]-4-(3,5-difluorophen yl)-2-oxo-, (4S)-
• CAS No.: 387826-86-0
• Molecular Formula: C26H30F2N4O4
• Molecular Weight: 500.545
• Mol file: 387826-86-0.mol

Synonyms:

Chemical Property of 3-Oxazolidinecarboxamide, N-[3-[4-[3-(acetylamino)phenyl]-1-piperidinyl]propyl]-4-(3,5-difluorophen yl)-2-oxo-, (4S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Oxazolidinecarboxamide, N-[3-[4-[3-(acetylamino)phenyl]-1-piperidinyl]propyl]-4-(3,5-difluorophen yl)-2-oxo-, (4S)-

There total 3 articles about 3-Oxazolidinecarboxamide, N-[3-[4-[3-(acetylamino)phenyl]-1-piperidinyl]propyl]-4-(3,5-difluorophen yl)-2-oxo-, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

N1-{3-[1-(3-aminopropyl)-4-piperidyl]phenyl}acetamide (387827-27-2) + 4-nitrophenyl (4S)-4-(3,5-difluorophenyl)-2-oxo-1,3-oxazolidine-3-carboxylate (387827-38-5) → (4S)-N-(3-{4-[3-(acetylamino)phenyl]-1-piperidinyl}propyl)-4-(3,5-difluorophenyl)-2-oxo-1,3-oxazolidine-3-carboxamide (387826-86-0)

Guidance literature:

In methanol; dichloromethane; at 20 ℃; for 3h;

Reference yield: 68.0%

(4S)-4-(3,5-difluorophenyl)-2-oxo-oxazolidine-3-carboxylic acid-4-nitro-phenyl ester + N1-{3-[1-(aminopropyl)-1,2,3,6-tetrahydro-4-pyridinyl]phenyl}acetamide → (4S)-N-(3-{4-[3-(acetylamino)phenyl]-1-piperidinyl}propyl)-4-(3,5-difluorophenyl)-2-oxo-1,3-oxazolidine-3-carboxamide (387826-86-0)

Guidance literature:

In methanol; dichloromethane;

Reference yield: 68.0%

(4S)-4-(3,5-difluorophenyl)-2-oxo-oxazolidine-3-carboxylic acid-4-nitro-phenyl ester + N1-{3-[1-(3-aminopropyl)-1,2,3,6-tetrahydro-4-pyridinyl] phenyl}acetamide (387827-23-8) → (4S)-N-(3-{4-[3-(acetylamino)phenyl]-1-piperidinyl}propyl)-4-(3,5-difluorophenyl)-2-oxo-1,3-oxazolidine-3-carboxamide (387826-86-0)

Guidance literature:

In methanol; dichloromethane;

upstream raw materials:

N₁-{3-[1-(3-aminopropyl)-4-piperidyl]phenyl}acetamide

4-nitrophenyl (4S)-4-(3,5-difluorophenyl)-2-oxo-1,3-oxazolidine-3-carboxylate

N₁-{3-[1-(3-aminopropyl)-1,2,3,6-tetrahydro-4-pyridinyl] phenyl}acetamide