1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 3-(1,1-dimethylethyl)-8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-, monohydrochloride

Base Information

Chemical Name:1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 3-(1,1-dimethylethyl)-8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-, monohydrochloride
CAS No.:134070-08-9
Molecular Formula:C20H30ClFN2O3
Molecular Weight:400.9152
Hs Code.:
DSSTox Substance ID:DTXSID30928420

Synonyms:134070-08-9;1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 3-(1,1-dimethylethyl)-8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-, monohydrochloride;C20H29FN2O3.ClH;DTXSID30928420;C20-H29-F-N2-O3.Cl-H;LS-98905;3-tert-Butyl-8-[2-(4-fluorophenyl)ethyl]-4-hydroxy-4-methyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one--hydrogen chloride (1/1)

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Chemical Property of 1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 3-(1,1-dimethylethyl)-8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-, monohydrochloride

Chemical Property:

Vapor Pressure:9.13E-12mmHg at 25°C
Boiling Point:523°C at 760 mmHg
Flash Point:270.1°C
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:400.1928987
Heavy Atom Count:27
Complexity:520

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C2(CCN(CC2)CCC3=CC=C(C=C3)F)OC(=O)N1C(C)(C)C)O.Cl

Technology Process of 1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 3-(1,1-dimethylethyl)-8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-, monohydrochloride

There total 3 articles about 1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 3-(1,1-dimethylethyl)-8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 134069-87-7
1-Oxa-2-oxo-3-tert-butyl-4-methylene-8-[2-(4-fluorophenyl)-ethyl]-3,8-diazaspiro[4,5]decane

: 134070-08-9
3-tert-Butyl-8-[2-(4-fluoro-phenyl)-ethyl]-4-hydroxy-4-methyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one; hydrochloride

Guidance literature:: With hydrogenchloride; formic acid; at 5 ℃;
DOI:10.1016/S0223-5234(97)84359-0

Reference yield:

: 4-ethynyl-4-hydroxyl-1-[2-(4-fluorophenyl)-ethyl]piperidine

: 134070-08-9
3-tert-Butyl-8-[2-(4-fluoro-phenyl)-ethyl]-4-hydroxy-4-methyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / CH₃ONa / toluene / 50 °C

2: 98 percent / formic acid, aq. HCl / 5 °C

With hydrogenchloride; formic acid; sodium methylate; In toluene;
DOI:10.1016/S0223-5234(97)84359-0

Reference yield:

: 1609-86-5
Tert-butyl isocyanate

: 134070-08-9
3-tert-Butyl-8-[2-(4-fluoro-phenyl)-ethyl]-4-hydroxy-4-methyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / CH₃ONa / toluene / 50 °C

2: 98 percent / formic acid, aq. HCl / 5 °C

With hydrogenchloride; formic acid; sodium methylate; In toluene;
DOI:10.1016/S0223-5234(97)84359-0