5-METHYL-2-(3-TRIFLUOROMETHYL-PHENYL)-2,4-DIHYDRO-PYRAZOL-3-ONE

Base Information

• Chemical Name: 5-METHYL-2-(3-TRIFLUOROMETHYL-PHENYL)-2,4-DIHYDRO-PYRAZOL-3-ONE
• CAS No.: 321-05-1
• Molecular Formula: C11H9 F3 N2 O
• Molecular Weight: 242.2
• Hs Code.: 2933199090
• Mol file: 321-05-1.mol

Synonyms:2-Pyrazolin-5-one,3-methyl-1-(a,a,a-trifluoro-m-tolyl)- (7CI,8CI); 1-(3-Trifluoromethylphenyl)-3-Methyl-2-pyrazolin-5-one;NSC 10362

Chemical Property of 5-METHYL-2-(3-TRIFLUOROMETHYL-PHENYL)-2,4-DIHYDRO-PYRAZOL-3-ONE

Chemical Property:

• Vapor Pressure: 5.76E-05mmHg at 25°C
• Boiling Point: 346.4°Cat760mmHg
• Flash Point: 163.3°C
• PSA: 32.67000
• Density: 1.35g/cm³
• LogP: 2.31860

Purity/Quality:

99% ^*data from raw suppliers

3-Methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5(4H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYL-2-(3-TRIFLUOROMETHYL-PHENYL)-2,4-DIHYDRO-PYRAZOL-3-ONE

There total 3 articles about 5-METHYL-2-(3-TRIFLUOROMETHYL-PHENYL)-2,4-DIHYDRO-PYRAZOL-3-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl acetoacetate (141-97-9) + 3-(trifluoromethyl)phenylhydrazine (368-78-5) → 5-methyl-2-[3-(trifluoromethyl)phenyl]-2,4-dihydropyrazol-3-one (321-05-1)

Guidance literature:

With acetic acid; at 100 ℃; for 24h;

DOI:10.1021/jm010283l

Reference yield: 76.0%

→ 5-methyl-2-[3-(trifluoromethyl)phenyl]-2,4-dihydropyrazol-3-one (321-05-1)

Guidance literature:

Reference yield:

ethyl acetoacetate (141-97-9) + 3-(trifluoromethyl)phenylhydrazine hydrochloride (3107-33-3,64123-92-8) → 5-methyl-2-[3-(trifluoromethyl)phenyl]-2,4-dihydropyrazol-3-one (321-05-1)

Guidance literature:

3-(trifluoromethyl)phenylhydrazine hydrochloride; With sodium acetate; In ethanol; water; at 20 ℃; for 0.0833333h; Inert atmosphere;

ethyl acetoacetate; In ethanol; water; for 3h; Inert atmosphere; Reflux;

DOI:10.1002/anie.201901511

upstream raw materials:

ethyl acetoacetate

3-(trifluoromethyl)phenylhydrazine

3-(trifluoromethyl)phenylhydrazine hydrochloride

Downstream raw materials:

2-(2-(cyclohexylamino)-5-(trifluoromethyl)phenyl)-5-methyl-1H-pyrazol-3(2H)-one

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