Propanedioic acid, [4-[[[4-[(1E)-2-[[(3-cyclohexylpropyl)(6-methoxy-6-oxohexyl)amino]sulfon yl]ethenyl]phenyl]amino]carbonyl]cyclohexylidene]-, diethyl ester

Base Information

Chemical Name:Propanedioic acid, [4-[[[4-[(1E)-2-[[(3-cyclohexylpropyl)(6-methoxy-6-oxohexyl)amino]sulfon yl]ethenyl]phenyl]amino]carbonyl]cyclohexylidene]-, diethyl ester
CAS No.:389140-53-8
Molecular Formula:C38H56N2O9S
Molecular Weight:716.937
Hs Code.:
Mol file:389140-53-8.mol

Propanedioic acid,
[4-[[[4-[(1E)-2-[[(3-cyclohexylpropyl)(6-methoxy-6-oxohexyl)amino]sulfon
yl]ethenyl]phenyl]amino]carbonyl]cyclohexylidene]-, diethyl ester

Synonyms:

Suppliers and Price of Propanedioic acid, [4-[[[4-[(1E)-2-[[(3-cyclohexylpropyl)(6-methoxy-6-oxohexyl)amino]sulfon yl]ethenyl]phenyl]amino]carbonyl]cyclohexylidene]-, diethyl ester

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Chemical Property of Propanedioic acid, [4-[[[4-[(1E)-2-[[(3-cyclohexylpropyl)(6-methoxy-6-oxohexyl)amino]sulfon yl]ethenyl]phenyl]amino]carbonyl]cyclohexylidene]-, diethyl ester

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Safty Information:

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Hazard Codes:

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Technology Process of Propanedioic acid, [4-[[[4-[(1E)-2-[[(3-cyclohexylpropyl)(6-methoxy-6-oxohexyl)amino]sulfon yl]ethenyl]phenyl]amino]carbonyl]cyclohexylidene]-, diethyl ester

There total 5 articles about Propanedioic acid, [4-[[[4-[(1E)-2-[[(3-cyclohexylpropyl)(6-methoxy-6-oxohexyl)amino]sulfon yl]ethenyl]phenyl]amino]carbonyl]cyclohexylidene]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 389140-37-8
4-bis-ethoxycarbonylmethylene-1-cyclohexanecarboxylic acid

: 745050-47-9
6-[[2-(4-tert-butoxycarbonylamino-phenyl)-ethenesulfonyl]-(3-cyclohexyl-propyl)-amino]-hexanoic acid methyl ester

: 389140-53-8
methyl 6-[(E)-2-[4-{(4-bis-ethoxycarbonylmethylene)cyclohexanecarbonylamino}phenyl]-N-(3-cyclohexylpropyl)ethenylsulfonamido]hexanoate

Guidance literature:: 4-bis-ethoxycarbonylmethylene-1-cyclohexanecarboxylic acid; With pyridine; dicyclohexyl-carbodiimide; for 1h; cooling;

6-[[2-(4-tert-butoxycarbonylamino-phenyl)-ethenesulfonyl]-(3-cyclohexyl-propyl)-amino]-hexanoic acid methyl ester; at 20 ℃; for 48h; Further stages.;
DOI:10.1021/jm010313k

Reference yield:

: ethyl 4-(tert-butoxycarbonylamino)cyclohexanecarboxylate

: 389140-53-8
methyl 6-[(E)-2-[4-{(4-bis-ethoxycarbonylmethylene)cyclohexanecarbonylamino}phenyl]-N-(3-cyclohexylpropyl)ethenylsulfonamido]hexanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 94 percent / diisobutylaluminium hydride / toluene / 2 h / -78 °C

2.1: 94 percent / MnO₂ / CHCl₃ / 12 h / 20 °C

3.1: n-butyl lithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

3.2: 95 percent / hexane; tetrahydrofuran / 1.5 h / -78 - 20 °C

4.1: 86 percent / acetone / 12 h / Heating

5.1: 92 percent / trifephenylphosphine; sulfuryl chloride / CHCl₃ / 2 h / cooling

6.1: 74 percent / triethylamine / CHCl₃ / 0.25 h / cooling

7.1: 72 percent / potassium carbonate / dimethylformamide / 5 h / 70 °C

8.1: pyridine; DCC / 1 h / cooling

8.2: 33 percent / 48 h / 20 °C

With pyridine; manganese(IV) oxide; n-butyllithium; sulfuryl dichloride; diisobutylaluminium hydride; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; hexane; chloroform; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jm010313k

Reference yield:

: 389140-41-4
(E)-2-[4-(tert-butoxycarbonylamino)phenyl]ethenylsulfonyl chloride

: 389140-53-8
methyl 6-[(E)-2-[4-{(4-bis-ethoxycarbonylmethylene)cyclohexanecarbonylamino}phenyl]-N-(3-cyclohexylpropyl)ethenylsulfonamido]hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 74 percent / triethylamine / CHCl₃ / 0.25 h / cooling

2.1: 72 percent / potassium carbonate / dimethylformamide / 5 h / 70 °C

3.1: pyridine; DCC / 1 h / cooling

3.2: 33 percent / 48 h / 20 °C

With pyridine; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm010313k