9H-Pyrido[3,4-b]indole-1-carboxamide

Base Information

• Chemical Name: 9H-Pyrido[3,4-b]indole-1-carboxamide
• CAS No.: 38940-60-2
• Molecular Formula: C12H9N3O
• Molecular Weight: 211.21900
• Mol file: 38940-60-2.mol

Synonyms:9H-β-Carboline-1-carboxylic acid amide;Harmane carboxamide;1-Karboxamidonorharman;1-β-carbolinylcarboxamide;9H-Pyrido[3,4-b]indole-1-carboxamide;1-Carbamoyl-β-carbolin;

Chemical Property of 9H-Pyrido[3,4-b]indole-1-carboxamide

Chemical Property:

• PSA: 71.77000
• LogP: 2.51530

Purity/Quality:

9H-Pyrido[3,4-b]indole-1-carboxamide 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9H-Pyrido[3,4-b]indole-1-carboxamide

There total 15 articles about 9H-Pyrido[3,4-b]indole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

methyl 9H-pyrido[3,4-b]indole-1-carboxylate (3464-66-2) → 9H-pyrido[3,4-b]indole-1-carboxamide (38940-60-2)

Guidance literature:

With ammonium hydroxide; In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2012.05.053

Reference yield: 80.0%

betacarboline (244-63-3) + formamide (77287-34-4,77287-35-5,60100-09-6) → 9H-pyrido[3,4-b]indole-1-carboxamide (38940-60-2)

Guidance literature:

With tert.-butylhydroperoxide; sulfuric acid; iron(II) sulfate; at 20 ℃;

DOI:10.1081/SCC-120026305

Reference yield: 76.0%

methyl 2,3,4,9-tetrahydro-1H-pyrido [3,4-b]indole-1-carboxylate (127661-45-4,130659-45-9) → 9H-pyrido[3,4-b]indole-1-carboxamide (38940-60-2)

Guidance literature:

With ammonium hydroxide; In methanol; at 20 ℃;

DOI:10.1016/j.ejmech.2021.113563

upstream raw materials:

9H-pyrido<3,4-b>indole-1-carboxylic acid

9H-pyrido[3,4-b]indole-1-carbonitrile

1-carbamoyl-1,2,3,4-tetrahydro-β-carboline

betacarboline

Downstream raw materials:

C₁₈H₁₄N₄O₃S

C₁₉H₁₆N₄O₃S

C₁₈H₁₃FN₄O₃S

eudistomin H

Refernces

• 1、 Wang, Yue,Jin, Qiaomei,Lin, Guowu,Yang, Taotao,Wang, Zhanwei,Lu, Yi,Tang, Yimin,Liu, Lifang,Lu, Tao. "Synthesis and structure of the β-carboline derivatives and their binding intensity with cyclin-dependent kinase 2". . p. 435 - 441. Retrieved 2012/05/04.
• 2、 Lin, Guowu,Wang, Yue,Zhou, Qingfa,Tang, Weifang,Wang, Jian,Lu, Tao. "A facile synthesis of 1-substituted βcarboline derivatives via minisci-reaction". experimental part. p. 3541 - 3550. Retrieved 2011/09/16.