TERT-BUTYL 4-(3-NITROBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 4-(3-NITROBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE
• CAS No.: 389628-56-2
• Molecular Formula: C₁₆H₂₁N₃O₅
• Molecular Weight: 335.36
• Mol file: 389628-56-2.mol

Synonyms:

Chemical Property of TERT-BUTYL 4-(3-NITROBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

tert-Butyl4-(3-nitrobenzoyl)piperazine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of TERT-BUTYL 4-(3-NITROBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

There total 2 articles about TERT-BUTYL 4-(3-NITROBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-t-Butoxycarbonylpiperazine (57260-71-6) + 3-nitrobenzoic acid (121-92-6) → tert-butyl 4-(3-nitrobenzoyl)piperazine-1-carboxylate (389628-56-2)

Guidance literature:

3-nitrobenzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

1-t-Butoxycarbonylpiperazine; In dichloromethane; at 20 ℃; for 5h;

Reference yield: 75.0%

m-nitrobenzoic acid chloride (121-90-4) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(3-nitrobenzoyl)piperazine-1-carboxylate (389628-56-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

tert-butyl 4-(3-nitrobenzoyl)piperazine-1-carboxylate (389628-56-2) → 4-{3-[3-(1-adamantyl)ureido]benzoyl}piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 12 h

2: dichloromethane / 12 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane;

upstream raw materials:

1-t-Butoxycarbonylpiperazine

3-nitrobenzoic acid

m-nitrobenzoic acid chloride

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