Phenylalanine, N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[3-(3-hydroxyphenyl)-1-oxopropyl]val yl-4-fluoro-3-nitro-, methyl ester

Base Information

Chemical Name:Phenylalanine, N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[3-(3-hydroxyphenyl)-1-oxopropyl]val yl-4-fluoro-3-nitro-, methyl ester
CAS No.:389634-89-3
Molecular Formula:C34H40FN3O9
Molecular Weight:653.705
Hs Code.:
Mol file:389634-89-3.mol

Synonyms:

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Chemical Property of Phenylalanine, N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[3-(3-hydroxyphenyl)-1-oxopropyl]val yl-4-fluoro-3-nitro-, methyl ester

Chemical Property:

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Technology Process of Phenylalanine, N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[3-(3-hydroxyphenyl)-1-oxopropyl]val yl-4-fluoro-3-nitro-, methyl ester

There total 3 articles about Phenylalanine, N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[3-(3-hydroxyphenyl)-1-oxopropyl]val yl-4-fluoro-3-nitro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 621-54-5
3-(3-hydroxyphenyl)-propanoic acid

: 389635-00-1
3-(4-fluoro-3-nitrophenyl)-2-isocyanopropionic acid methyl ester

: 459831-95-9
[2-(3,4-dimethoxyphenyl)ethyl](isobutylidene)amine

: 389634-89-3
2-(2-{[2-(3,4-dimethoxy-phenyl)-ethyl]-[3-(3-hydroxy-phenyl)-propionyl]-amino}-3-methyl-butyrylamino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester

Guidance literature:: With ammonium chloride; In toluene; at 60 ℃; for 20h;
DOI:10.1016/j.tet.2003.08.031

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 389634-89-3
2-(2-{[2-(3,4-dimethoxy-phenyl)-ethyl]-[3-(3-hydroxy-phenyl)-propionyl]-amino}-3-methyl-butyrylamino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 1 h / 20 °C

2: NH₄Cl / toluene / 20 h / 60 °C

With ammonium chloride; In toluene; 2: Ugi reaction;
DOI:10.1016/j.tet.2003.08.031

Reference yield:

: 3-(4-fluoro-3-nitro-phenyl)-2-formylamino-propionic acid methyl ester

: 389634-89-3
2-(2-{[2-(3,4-dimethoxy-phenyl)-ethyl]-[3-(3-hydroxy-phenyl)-propionyl]-amino}-3-methyl-butyrylamino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃; Et₃N / CH₂Cl₂ / 5 h / -25 °C

2: NH₄Cl / toluene / 20 h / 60 °C

With ammonium chloride; triethylamine; trichlorophosphate; In dichloromethane; toluene; 2: Ugi reaction;
DOI:10.1016/j.tet.2003.08.031