1-[(Benzyloxy)carbonyl]pyrrolidin-3-aminium

Base Information

Chemical Name:1-[(Benzyloxy)carbonyl]pyrrolidin-3-aminium
CAS No.:122536-73-6
Molecular Formula:C12H16N2O2
Molecular Weight:220.271
Hs Code.:29339900
DSSTox Substance ID:DTXSID00924196
Wikidata:Q72516005
Mol file:122536-73-6.mol

Synonyms:DTXSID00924196;1-[(Benzyloxy)carbonyl]pyrrolidin-3-aminium

Suppliers and Price of 1-[(Benzyloxy)carbonyl]pyrrolidin-3-aminium

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-3-Amino-1-N-CBZ-Pyrrolidine
500mg
$ 75.00

SynQuest Laboratories
(R)-3-Amino-1-Cbz-pyrrolidine
25 g
$ 550.00

SynQuest Laboratories
(R)-3-Amino-1-Cbz-pyrrolidine
5 g
$ 150.00

SynQuest Laboratories
(R)-3-Amino-1-Cbz-pyrrolidine
1 g
$ 90.00

Sigma-Aldrich
(R)-(?)-1-Cbz-3-aminopyrrolidine 97%
1g
$ 110.00

Matrix Scientific
(R)-3-Amino-1-Cbz-pyrrolidine
5g
$ 781.00

Matrix Scientific
(R)-3-Amino-1-Cbz-pyrrolidine
1g
$ 284.00

Crysdot
(3R)-1-N-Cbz-3-Aminopyrrolidine 97%
25g
$ 396.00

Crysdot
(3R)-1-N-Cbz-3-Aminopyrrolidine 97%
1g
$ 40.00

Crysdot
(3R)-1-N-Cbz-3-Aminopyrrolidine 97%
5g
$ 119.00

Total 88 raw suppliers

Chemical Property of 1-[(Benzyloxy)carbonyl]pyrrolidin-3-aminium

Chemical Property:

Vapor Pressure:3.37E-06mmHg at 25°C
Melting Point:310-316℃
Refractive Index:n20/D 1.548
Boiling Point:351.7 °C at 760 mmHg
Flash Point:166.5 °C
PSA：55.56000
Density:1.186 g/cm³
LogP:1.99440
Sensitive.:Air Sensitive
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:221.129002789
Heavy Atom Count:16
Complexity:239

Purity/Quality:

99% ^*data from raw suppliers

(R)-3-Amino-1-N-CBZ-Pyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CC1[NH3+])C(=O)OCC2=CC=CC=C2
Isomeric SMILES:C1CN(C[C@@H]1[NH3+])C(=O)OCC2=CC=CC=C2
Uses (R)-(?)-1-Cbz-3-aminopyrrolidine can be used:In one of the key synthetic steps for the preparations of AZ82, a KIFC1-specific inhibitor for cancer therapy.As a key intermediate in the synthesis of N6-substituted adenosine analogs as potent A1AR agonists.

Technology Process of 1-[(Benzyloxy)carbonyl]pyrrolidin-3-aminium

There total 7 articles about 1-[(Benzyloxy)carbonyl]pyrrolidin-3-aminium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 31139-36-3
dibenzyl dicarbonate

: 116183-82-5
(R)-pyrrolidin-3-amine

: 122536-73-6
benzyl (R)-3-amino-pyrrolidine-1-carboxylate

Guidance literature:: With hydrogenchloride; In methanol; at 0 ℃; for 2.5h;
DOI:10.1016/j.bmcl.2007.10.028

Reference yield:

: 122536-71-4
(R)-3-azido-1-pyrrolidinecarboxylic acid phenylmethyl ester

: 122536-73-6
benzyl (R)-3-amino-pyrrolidine-1-carboxylate

Guidance literature:: With hydrogen; nickel; In methanol; at 21.5 - 25 ℃; for 21.5h; under 2585.7 Torr;
DOI:10.1021/jm00088a011

Reference yield:

: 122536-69-0
(S)-3-<(methylsulfonyl)oxy>-1-pyrrolidinecarboxylic acid phenylmethyl ester

: 122536-73-6
benzyl (R)-3-amino-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / dimethylformamide / 2 h / 100 °C

2: H₂ / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr

With sodium azide; hydrogen; nickel; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a011