3-Quinolinecarboxamide, N-[(4-chlorophenyl)methyl]-1,4-dihydro-8-(3-hydroxy-1-propynyl)-1-meth yl-6-(4-morpholinylmethyl)-4-oxo-

Base Information

• Chemical Name: 3-Quinolinecarboxamide, N-[(4-chlorophenyl)methyl]-1,4-dihydro-8-(3-hydroxy-1-propynyl)-1-meth yl-6-(4-morpholinylmethyl)-4-oxo-
• CAS No.: 390375-47-0
• Molecular Formula: C26H26ClN3O4
• Molecular Weight: 479.963
• Mol file: 390375-47-0.mol

Synonyms:

Chemical Property of 3-Quinolinecarboxamide, N-[(4-chlorophenyl)methyl]-1,4-dihydro-8-(3-hydroxy-1-propynyl)-1-meth yl-6-(4-morpholinylmethyl)-4-oxo-

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-Quinolinecarboxamide, N-[(4-chlorophenyl)methyl]-1,4-dihydro-8-(3-hydroxy-1-propynyl)-1-meth yl-6-(4-morpholinylmethyl)-4-oxo-

There total 1 articles about 3-Quinolinecarboxamide, N-[(4-chlorophenyl)methyl]-1,4-dihydro-8-(3-hydroxy-1-propynyl)-1-meth yl-6-(4-morpholinylmethyl)-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-chlorobenzyl)-8-iodo-1-methyl-6-(4-morpholinylmethyl)-4-oxo-1,4-dihydro-3-quinolinecarboxamide + propargyl alcohol (107-19-7) → N-(4-chlorobenzyl)-8-(3-hydroxy-1-propynyl)-1-methyl-6-(4-morpholinylmethyl)-4-oxo-1,4-dihydro-3-quinolinecarboxamide (390375-47-0)

Guidance literature:

With CuI; bis-triphenylphosphine-palladium(II) chloride; In methanol; dichloromethane; diethylamine;

Reference yield:

N-(4-chlorobenzyl)-8-(3-hydroxy-1-propynyl)-1-methyl-6-(4-morpholinylmethyl)-4-oxo-1,4-dihydro-3-quinolinecarboxamide (390375-47-0) → N-(4-chlorobenzyl)-8-{3-[3-(hydroxymethyl)piperidin-1-yl]prop-1-ynyl}-1-methyl-6-(morpholin-4-ylmethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (458524-84-0)

Guidance literature:

With triethylamine; lithium chloride; In dichloromethane;

Reference yield:

N-(4-chlorobenzyl)-8-(3-hydroxy-1-propynyl)-1-methyl-6-(4-morpholinylmethyl)-4-oxo-1,4-dihydro-3-quinolinecarboxamide (390375-47-0) → N-(4-chlorobenzyl)-8-{3-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]prop-1-ynyl}-1-methyl-6-(morpholin-4-ylmethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (458524-86-2)

Guidance literature:

With triethylamine; In dichloromethane;

upstream raw materials:

propargyl alcohol

Downstream raw materials:

N-(4-chlorobenzyl)-8-{3-[4-(2-hydroxyethyl)piperazin-1-yl]prop-1-ynyl}1-methyl-6-(morpholin-4-ylmethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

N-(4-chlorobenzyl)-8-{3-[2-(2-hydroxyethyl)piperidin-1-yl]prop-1-ynyl}-1-methyl-6-(morpholin-4-ylmethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

N-(4-chlorobenzyl)-8-{3-[3-(hydroxymethyl)piperidin-1-yl]prop-1-ynyl}-1-methyl-6-(morpholin-4-ylmethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

N-(4-chlorobenzyl)-8-{3-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]prop-1-ynyl}-1-methyl-6-(morpholin-4-ylmethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

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