3,4-Pyridazinedicarboxylic acid, 2,3-dihydro-2-phenyl-6-(2-thienylcarbonyl)-, dihydrazide

Base Information

• Chemical Name: 3,4-Pyridazinedicarboxylic acid, 2,3-dihydro-2-phenyl-6-(2-thienylcarbonyl)-, dihydrazide
• CAS No.: 390375-72-1
• Molecular Formula: C17H16N6O3S
• Molecular Weight: 384.418
• Mol file: 390375-72-1.mol

Synonyms:

Chemical Property of 3,4-Pyridazinedicarboxylic acid, 2,3-dihydro-2-phenyl-6-(2-thienylcarbonyl)-, dihydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-Pyridazinedicarboxylic acid, 2,3-dihydro-2-phenyl-6-(2-thienylcarbonyl)-, dihydrazide

There total 2 articles about 3,4-Pyridazinedicarboxylic acid, 2,3-dihydro-2-phenyl-6-(2-thienylcarbonyl)-, dihydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Dimethyl 1,6-dihydro-1-phenyl-3-(2-thienoyl)pyridazine-5,6-dicarboxylate (390375-69-6) → 1,6-Dihydro-1-phenyl-3-(2-thienoyl)pyridazine-5,6-dicarboxydihydrazide (390375-72-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Heating;

DOI:10.1055/s-2001-17522

Reference yield:

3-oxo-2-(phenylhydrazono)-3-(thiophen-2-yl)propionaldehyde (337512-14-8) → 1,6-Dihydro-1-phenyl-3-(2-thienoyl)pyridazine-5,6-dicarboxydihydrazide (390375-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / Ph₃P / CH₂Cl₂ / 24 h / 20 °C

2: 95 percent / hydrazine hydrate / ethanol / 1 h / Heating

With hydrazine hydrate; triphenylphosphine; In ethanol; dichloromethane;

DOI:10.1055/s-2001-17522

Reference yield: 95.0%

1,6-Dihydro-1-phenyl-3-(2-thienoyl)pyridazine-5,6-dicarboxydihydrazide (390375-72-1) → 8-Hydrazino-1-phenyl-1,5,6,8a-tetrahydro-3-(2-thienoyl)pyridazino[3,4-d]pyridazin-5-one

Guidance literature:

In N,N-dimethyl-formamide; for 1h; Heating;

DOI:10.1055/s-2001-17522

upstream raw materials:

Dimethyl 1,6-dihydro-1-phenyl-3-(2-thienoyl)pyridazine-5,6-dicarboxylate

3-oxo-2-(phenylhydrazono)-3-(thiophen-2-yl)propionaldehyde