1-Pyrrolidinecarboxylic acid, 2-[4-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-butenyl]phenyl]-4-[[ (1,1-dimethylethyl)dimethylsilyl]oxy]-, 1,1-dimethylethyl ester, (2R,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[4-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-butenyl]phenyl]-4-[[ (1,1-dimethylethyl)dimethylsilyl]oxy]-, 1,1-dimethylethyl ester, (2R,4R)-
CAS No.:390423-98-0
Molecular Formula:C30H50N2O5Si
Molecular Weight:546.823
Hs Code.:
Mol file:390423-98-0.mol

1-Pyrrolidinecarboxylic acid,
2-[4-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-butenyl]phenyl]-4-[[
(1,1-dimethylethyl)dimethylsilyl]oxy]-, 1,1-dimethylethyl ester, (2R,4R)-

Synonyms:

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[4-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-butenyl]phenyl]-4-[[ (1,1-dimethylethyl)dimethylsilyl]oxy]-, 1,1-dimethylethyl ester, (2R,4R)-

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Purity/Quality:

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[4-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-butenyl]phenyl]-4-[[ (1,1-dimethylethyl)dimethylsilyl]oxy]-, 1,1-dimethylethyl ester, (2R,4R)-

There total 5 articles about 1-Pyrrolidinecarboxylic acid, 2-[4-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-butenyl]phenyl]-4-[[ (1,1-dimethylethyl)dimethylsilyl]oxy]-, 1,1-dimethylethyl ester, (2R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 2-[4-(1-amino-but-3-enyl)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 390423-98-0
2-[4-(1-tert-butoxycarbonylamino-but-3-enyl)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 0 ℃;
DOI:10.1055/s-2001-18100

Reference yield:

: 228267-22-9
(2R,4R)-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-(4-formylphenyl)pyrrolidine

: 390423-98-0
2-[4-(1-tert-butoxycarbonylamino-but-3-enyl)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / Et₃N; MgSO₄ / tetrahydrofuran / 20 °C

2: 77 percent / Zn / dimethylformamide / 60 °C

3: 85 percent / LiAlH₄ / tetrahydrofuran / 0 °C

4: H₅IO₆; MeNH₂ / aq. methanol / 0 °C

5: aq. NaOH / dioxane / 0 °C

With sodium hydroxide; lithium aluminium tetrahydride; magnesium sulfate; periodic acid; triethylamine; methylamine; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1055/s-2001-18100

Reference yield:

: (2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(4-{[(E)-(S)-1-methoxycarbonyl-2-methyl-propylimino]-methyl}-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 390423-98-0
2-[4-(1-tert-butoxycarbonylamino-but-3-enyl)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / Zn / dimethylformamide / 60 °C

2: 85 percent / LiAlH₄ / tetrahydrofuran / 0 °C

3: H₅IO₆; MeNH₂ / aq. methanol / 0 °C

4: aq. NaOH / dioxane / 0 °C

With sodium hydroxide; lithium aluminium tetrahydride; periodic acid; methylamine; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1055/s-2001-18100