5-Oxazolol, 4-[(3-bromo-4-hydroxyphenyl)methyl]-2-(trifluoromethyl)-

Base Information

Chemical Name:5-Oxazolol, 4-[(3-bromo-4-hydroxyphenyl)methyl]-2-(trifluoromethyl)-
CAS No.:390424-24-5
Molecular Formula:C₁₁H₇BrF₃NO₃
Molecular Weight:338.081
Hs Code.:
DSSTox Substance ID:DTXSID60459979
Wikidata:Q82283877
Mol file:390424-24-5.mol

Synonyms:390424-24-5;4-(3-Bromo-4-hydroxybenzyl)-2-(trifluoromethyl)oxazol-5-ol;5-Oxazolol, 4-[(3-bromo-4-hydroxyphenyl)methyl]-2-(trifluoromethyl)-;DTXSID60459979

Suppliers and Price of 5-Oxazolol, 4-[(3-bromo-4-hydroxyphenyl)methyl]-2-(trifluoromethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Oxazolol, 4-[(3-bromo-4-hydroxyphenyl)methyl]-2-(trifluoromethyl)-

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:336.95614
Heavy Atom Count:19
Complexity:318

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1CC2=C(OC(=N2)C(F)(F)F)O)Br)O

Technology Process of 5-Oxazolol, 4-[(3-bromo-4-hydroxyphenyl)methyl]-2-(trifluoromethyl)-

There total 1 articles about 5-Oxazolol, 4-[(3-bromo-4-hydroxyphenyl)methyl]-2-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38739-13-8,7298-91-1
(2S)-2-amino-3-(3-bromo-4-hydroxyphenyl)propanoic acid

: 407-25-0
trifluoroacetic anhydride

: 390424-24-5
4-(3-bromo-4-hydroxy-benzyl)-2-trifluoromethyl-oxazol-5-ol

Guidance literature:: for 12h; Heating;
DOI:10.1002/1521-3765(20011001)7:19<4280::AID-CHEM4280>3.0.CO;2-3

Reference yield:

: 390424-24-5
4-(3-bromo-4-hydroxy-benzyl)-2-trifluoromethyl-oxazol-5-ol

: 390424-25-6
3-(3-bromo-4-hydroxyphenyl)-2-oxopropionic acid

Guidance literature:: With trifluoroacetic acid; at 23 ℃; for 24h;
DOI:10.1002/1521-3765(20011001)7:19<4280::AID-CHEM4280>3.0.CO;2-3

Reference yield:

: 390424-24-5
4-(3-bromo-4-hydroxy-benzyl)-2-trifluoromethyl-oxazol-5-ol

: 3-(3-Bromo-4-hydroxy-phenyl)-2-[(E)-methoxyimino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 6.34 g / aq. TFA / 24 h / 23 °C

2: ethanol / 12 h / 23 °C

3: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / dioxane / 2 h / 23 °C

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In 1,4-dioxane; ethanol;
DOI:10.1002/1521-3765(20011001)7:19<4280::AID-CHEM4280>3.0.CO;2-3