8,9-Dithia-2,5,12,15-tetraazahexadecanedioic acid, 3,14-bis[(4-nitrophenyl)methyl]-4,13-dioxo-, bis(1,1-dimethylethyl) ester, (3S,14S)-

Base Information

Chemical Name:8,9-Dithia-2,5,12,15-tetraazahexadecanedioic acid, 3,14-bis[(4-nitrophenyl)methyl]-4,13-dioxo-, bis(1,1-dimethylethyl) ester, (3S,14S)-
CAS No.:390424-55-2
Molecular Formula:C32H44N6O10S2
Molecular Weight:736.868
Hs Code.:
Mol file:390424-55-2.mol

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Chemical Property of 8,9-Dithia-2,5,12,15-tetraazahexadecanedioic acid, 3,14-bis[(4-nitrophenyl)methyl]-4,13-dioxo-, bis(1,1-dimethylethyl) ester, (3S,14S)-

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Technology Process of 8,9-Dithia-2,5,12,15-tetraazahexadecanedioic acid, 3,14-bis[(4-nitrophenyl)methyl]-4,13-dioxo-, bis(1,1-dimethylethyl) ester, (3S,14S)-

There total 4 articles about 8,9-Dithia-2,5,12,15-tetraazahexadecanedioic acid, 3,14-bis[(4-nitrophenyl)methyl]-4,13-dioxo-, bis(1,1-dimethylethyl) ester, (3S,14S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56-17-7
cystamine dihydrochioride

: 53871-85-5
Boc-Phe(pNO₂)-OSu

: 390424-55-2
[1-(2-{2-[2-tert-butoxycarbonylamino-3-(4-nitro-phenyl)-propionylamino]-ethyldisulfanyl}-ethylcarbamoyl)-2-(4-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In 1,4-dioxane; methanol; at 23 ℃; for 12h;
DOI:10.1002/1521-3765(20011001)7:19<4280::AID-CHEM4280>3.0.CO;2-3

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 390424-55-2
[1-(2-{2-[2-tert-butoxycarbonylamino-3-(4-nitro-phenyl)-propionylamino]-ethyldisulfanyl}-ethylcarbamoyl)-2-(4-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaHCO₃ / tetrahydrofuran / 12 h / 23 °C

2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / dioxane / 2 h / 23 °C

3: Et₃N / dioxane; methanol / 12 h / 23 °C

With sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1002/1521-3765(20011001)7:19<4280::AID-CHEM4280>3.0.CO;2-3

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 390424-55-2
[1-(2-{2-[2-tert-butoxycarbonylamino-3-(4-nitro-phenyl)-propionylamino]-ethyldisulfanyl}-ethylcarbamoyl)-2-(4-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / dioxane / 2 h / 23 °C

2: Et₃N / dioxane; methanol / 12 h / 23 °C

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In 1,4-dioxane; methanol;
DOI:10.1002/1521-3765(20011001)7:19<4280::AID-CHEM4280>3.0.CO;2-3