2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 10-[5-(3-ethoxy-3-oxopropyl)-3-furanyl]-1-oxo-7-(phenylsulfonyl)-, 1,1-dimethylethyl ester

Base Information

Chemical Name:2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 10-[5-(3-ethoxy-3-oxopropyl)-3-furanyl]-1-oxo-7-(phenylsulfonyl)-, 1,1-dimethylethyl ester
CAS No.:390748-08-0
Molecular Formula:C28H34N2O8S
Molecular Weight:558.653
Hs Code.:
Mol file:390748-08-0.mol

2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid,
10-[5-(3-ethoxy-3-oxopropyl)-3-furanyl]-1-oxo-7-(phenylsulfonyl)-,
1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 10-[5-(3-ethoxy-3-oxopropyl)-3-furanyl]-1-oxo-7-(phenylsulfonyl)-, 1,1-dimethylethyl ester

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Technology Process of 2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 10-[5-(3-ethoxy-3-oxopropyl)-3-furanyl]-1-oxo-7-(phenylsulfonyl)-, 1,1-dimethylethyl ester

There total 16 articles about 2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 10-[5-(3-ethoxy-3-oxopropyl)-3-furanyl]-1-oxo-7-(phenylsulfonyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 390748-07-9
ethyl 3-[4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-2-furyl]propanoate

: 390747-99-6
7-benzenesulfonyl-1-oxo-10-trifluoromethanesulfonyloxy-2,7-diaza-spiro[4.5]dec-9-ene-2-carboxylic acid tert-butyl ester

: 390748-08-0
7-benzenesulfonyl-10-[5-(2-ethoxycarbonyl-ethyl)-furan-3-yl]-1-oxo-2,7-diaza-spiro[4.5]dec-9-ene-2-carboxylic acid tert-butyl ester

Guidance literature:: With sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 7h;
DOI:10.1016/S0040-4039(01)01792-0

Reference yield:

: 21921-76-6
4-bromo-2-furancarbaldehyde

: 390748-08-0
7-benzenesulfonyl-10-[5-(2-ethoxycarbonyl-ethyl)-furan-3-yl]-1-oxo-2,7-diaza-spiro[4.5]dec-9-ene-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: t-BuONa / tetrahydrofuran

2: NaBH₄ / NiCl₂ / ethanol / 0 °C

3: 74 percent / AcOK / PdCl₂(dppf) / dimethylsulfoxide

4: LiCl; Na₂CO₃ / Pd(PPh₃)4 / H₂O; 1,2-dimethoxy-ethane / 7 h / 80 °C

With sodium tetrahydroborate; potassium acetate; sodium carbonate; lithium chloride; sodium t-butanolate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide; 1: Wadsworth-Emmons-Horner reaction / 4: Suzuki-Miyaura coupling;
DOI:10.1016/S0040-4039(01)01792-0

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 390748-08-0
7-benzenesulfonyl-10-[5-(2-ethoxycarbonyl-ethyl)-furan-3-yl]-1-oxo-2,7-diaza-spiro[4.5]dec-9-ene-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 63 percent / Et₃N; DMAP

2.1: LiN(TMS)2 / tetrahydrofuran / -65 °C

2.2: 50 percent / 3 °C

3.1: LiCl; Na₂CO₃ / Pd(PPh₃)4 / H₂O; 1,2-dimethoxy-ethane / 7 h / 80 °C

With dmap; sodium carbonate; triethylamine; lithium chloride; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 3.1: Suzuki-Miyaura coupling;
DOI:10.1016/S0040-4039(01)01792-0