Heptanedioic acid, 2-[[(4-methylphenyl)sulfonyl][(phenylmethoxy)carbonyl]amino]-6-[[(phenyl methoxy)carbonyl]amino]-, dimethyl ester, (6S)-

Base Information

Chemical Name:Heptanedioic acid, 2-[[(4-methylphenyl)sulfonyl][(phenylmethoxy)carbonyl]amino]-6-[[(phenyl methoxy)carbonyl]amino]-, dimethyl ester, (6S)-
CAS No.:391594-68-6
Molecular Formula:C32H36N2O10S
Molecular Weight:640.711
Hs Code.:

Heptanedioic acid,
2-[[(4-methylphenyl)sulfonyl][(phenylmethoxy)carbonyl]amino]-6-[[(phenyl
methoxy)carbonyl]amino]-, dimethyl ester, (6S)-

Synonyms:

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Chemical Property of Heptanedioic acid, 2-[[(4-methylphenyl)sulfonyl][(phenylmethoxy)carbonyl]amino]-6-[[(phenyl methoxy)carbonyl]amino]-, dimethyl ester, (6S)-

Chemical Property:

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Technology Process of Heptanedioic acid, 2-[[(4-methylphenyl)sulfonyl][(phenylmethoxy)carbonyl]amino]-6-[[(phenyl methoxy)carbonyl]amino]-, dimethyl ester, (6S)-

There total 5 articles about Heptanedioic acid, 2-[[(4-methylphenyl)sulfonyl][(phenylmethoxy)carbonyl]amino]-6-[[(phenyl methoxy)carbonyl]amino]-, dimethyl ester, (6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 18303-10-1
benzyl N-(4-methylbenzenesulfonyl)carbamate

: 391594-67-5
dimethyl (2RS,6S)-2-hydroxy-6-[N-(benzyloxycarbonyl)-amino]heptane-1,7-dioate

: 391594-68-6
dimethyl (2RS,6S)-2-[N-(benzyloxycarbonyl)-N-(p-tolylsulfonyl)amino]-6-[N-(benzyloxycarbonyl)amino]heptane-1,7-dioate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1039/b105091p

Reference yield:

: 16338-48-0
L-allylglycine

: 391594-68-6
dimethyl (2RS,6S)-2-[N-(benzyloxycarbonyl)-N-(p-tolylsulfonyl)amino]-6-[N-(benzyloxycarbonyl)amino]heptane-1,7-dioate

Guidance literature:: Multi-step reaction with 5 steps

1: TMSCl / 0 - 20 °C

2: 1.06 g / Et₃N / 3 h / 0 °C

3: 79 percent / SnCl₄ / CH₂Cl₂ / 5 h / -78 - -25 °C

4: 86 percent / H₂ / 5 percent Rh/C / ethyl acetate / 48 h

5: 75 percent / PPh₃; DEAD / tetrahydrofuran / 5 h / 20 °C

With chloro-trimethyl-silane; hydrogen; tin(IV) chloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; Rh on carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; 5: Mitsunobu reaction;
DOI:10.1039/b105091p

Reference yield:

: 50299-15-5,70837-19-3,81136-73-4,105929-46-2
methyl (S)-allylglycinate

: 391594-68-6
dimethyl (2RS,6S)-2-[N-(benzyloxycarbonyl)-N-(p-tolylsulfonyl)amino]-6-[N-(benzyloxycarbonyl)amino]heptane-1,7-dioate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.06 g / Et₃N / 3 h / 0 °C

2: 79 percent / SnCl₄ / CH₂Cl₂ / 5 h / -78 - -25 °C

3: 86 percent / H₂ / 5 percent Rh/C / ethyl acetate / 48 h

4: 75 percent / PPh₃; DEAD / tetrahydrofuran / 5 h / 20 °C

With hydrogen; tin(IV) chloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; Rh on carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; 4: Mitsunobu reaction;
DOI:10.1039/b105091p