Carbamic acid, [(2S)-3-[4-(1,1-dimethylethoxy)phenyl]-2-[[(9H-fluoren-9-ylmethoxy)carb onyl]amino]propyl]-, 4-nitrophenyl ester

Base Information

Chemical Name:Carbamic acid, [(2S)-3-[4-(1,1-dimethylethoxy)phenyl]-2-[[(9H-fluoren-9-ylmethoxy)carb onyl]amino]propyl]-, 4-nitrophenyl ester
CAS No.:391624-41-2
Molecular Formula:C₃₅H₃₅N₃O₇
Molecular Weight:609.679
Hs Code.:
Mol file:391624-41-2.mol

Synonyms:

Suppliers and Price of Carbamic acid, [(2S)-3-[4-(1,1-dimethylethoxy)phenyl]-2-[[(9H-fluoren-9-ylmethoxy)carb onyl]amino]propyl]-, 4-nitrophenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Carbamic acid, [(2S)-3-[4-(1,1-dimethylethoxy)phenyl]-2-[[(9H-fluoren-9-ylmethoxy)carb onyl]amino]propyl]-, 4-nitrophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Carbamic acid, [(2S)-3-[4-(1,1-dimethylethoxy)phenyl]-2-[[(9H-fluoren-9-ylmethoxy)carb onyl]amino]propyl]-, 4-nitrophenyl ester

There total 4 articles about Carbamic acid, [(2S)-3-[4-(1,1-dimethylethoxy)phenyl]-2-[[(9H-fluoren-9-ylmethoxy)carb onyl]amino]propyl]-, 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71989-38-3,118488-18-9,204384-67-8
Fmoc-Tyr(tBu)-OH

: 391624-41-2
[3-(4-tert-butoxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propyl]-carbamic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: NMM; ICF / 1,2-dimethoxy-ethane / 1 h / -15 °C

1.2: 95 percent / NaBH₄ / 1,2-dimethoxy-ethane; H₂O / -15 °C

2.1: 87 percent / DEAD; PPh₃; HN₃ / benzene / 20 °C

3.1: H₂ / 10percent Pd/C / tetrahydrofuran; CHCl₃ / 20 °C

4.1: 3.38 g / DiPEA / CH₂Cl₂ / 0 - 20 °C

With 4-methyl-morpholine; tris-(2-chloro-ethyl)-amine; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; 10percent Pd/C; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; chloroform; benzene; 2.1: Mitsunobu reaction;
DOI:10.1021/jo010656q

Reference yield:

: 187526-99-4
(9H-fluoren-9-yl)methyl (S)-(1-(4-(tert-butoxy)phenyl)-3-hydroxypropan-2-yl)carbamate

: 391624-41-2
[3-(4-tert-butoxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propyl]-carbamic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / DEAD; PPh₃; HN₃ / benzene / 20 °C

2: H₂ / 10percent Pd/C / tetrahydrofuran; CHCl₃ / 20 °C

3: 3.38 g / DiPEA / CH₂Cl₂ / 0 - 20 °C

With tris-(2-chloro-ethyl)-amine; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; 10percent Pd/C; In tetrahydrofuran; dichloromethane; chloroform; benzene; 1: Mitsunobu reaction;
DOI:10.1021/jo010656q

Reference yield:

: 391624-31-0
[1-azidomethyl-2-(4-tert-butoxy-phenyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

: 391624-41-2
[3-(4-tert-butoxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propyl]-carbamic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / tetrahydrofuran; CHCl₃ / 20 °C

2: 3.38 g / DiPEA / CH₂Cl₂ / 0 - 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; 10percent Pd/C; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jo010656q