1,3-Propanedione, 1-[(1S)-2,3-dihydro-1-[1-hydroxy-3-(phenylthio)-2-propynyl]-7-methoxy-1 H-inden-1-yl]-3-[4,5-dimethoxy-2-(phenylmethoxy)phenyl]-

Base Information

Chemical Name:1,3-Propanedione, 1-[(1S)-2,3-dihydro-1-[1-hydroxy-3-(phenylthio)-2-propynyl]-7-methoxy-1 H-inden-1-yl]-3-[4,5-dimethoxy-2-(phenylmethoxy)phenyl]-
CAS No.:391859-25-9
Molecular Formula:C₃₇H₃₄O₇S
Molecular Weight:622.739
Hs Code.:
Mol file:391859-25-9.mol

1,3-Propanedione,
1-[(1S)-2,3-dihydro-1-[1-hydroxy-3-(phenylthio)-2-propynyl]-7-methoxy-1
H-inden-1-yl]-3-[4,5-dimethoxy-2-(phenylmethoxy)phenyl]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3-Propanedione, 1-[(1S)-2,3-dihydro-1-[1-hydroxy-3-(phenylthio)-2-propynyl]-7-methoxy-1 H-inden-1-yl]-3-[4,5-dimethoxy-2-(phenylmethoxy)phenyl]-

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Technology Process of 1,3-Propanedione, 1-[(1S)-2,3-dihydro-1-[1-hydroxy-3-(phenylthio)-2-propynyl]-7-methoxy-1 H-inden-1-yl]-3-[4,5-dimethoxy-2-(phenylmethoxy)phenyl]-

There total 6 articles about 1,3-Propanedione, 1-[(1S)-2,3-dihydro-1-[1-hydroxy-3-(phenylthio)-2-propynyl]-7-methoxy-1 H-inden-1-yl]-3-[4,5-dimethoxy-2-(phenylmethoxy)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-Benzyloxy-4,5-dimethoxy-benzoic acid 1-((S)-1-acetyl-7-methoxy-indan-1-yl)-3-phenylsulfanyl-prop-2-ynyl ester

: 391859-25-9
1-(2-Benzyloxy-4,5-dimethoxy-phenyl)-3-[(S)-1-(1-hydroxy-3-phenylsulfanyl-prop-2-ynyl)-7-methoxy-indan-1-yl]-propane-1,3-dione

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/ol016696y

Reference yield:

: 302336-24-9
(R)-(1-hydroxymethyl-7-methoxyindan-1-yl)methyl 2-furoate

: 391859-25-9
1-(2-Benzyloxy-4,5-dimethoxy-phenyl)-3-[(S)-1-(1-hydroxy-3-phenylsulfanyl-prop-2-ynyl)-7-methoxy-indan-1-yl]-propane-1,3-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: Dess-Martin periodinane / acetonitrile

1.2: 92 percent / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O

2.1: 49 percent / HMPA / tetrahydrofuran

3.1: 100 percent / Dess-Martin periodinane / acetonitrile

4.1: HMPA / tetrahydrofuran / -78 °C

5.1: DMAP / CH₂Cl₂

6.1: LiN(TMS)2 / tetrahydrofuran

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; Dess-Martin periodane; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetonitrile; 1.1: Dess-Martin oxidation / 3.1: Dess-Martin oxidation;
DOI:10.1021/ol016696y

Reference yield:

: 391859-24-8
(S)-1-Acetyl-7-methoxy-indan-1-carbaldehyde

: 391859-25-9
1-(2-Benzyloxy-4,5-dimethoxy-phenyl)-3-[(S)-1-(1-hydroxy-3-phenylsulfanyl-prop-2-ynyl)-7-methoxy-indan-1-yl]-propane-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: HMPA / tetrahydrofuran / -78 °C

2: DMAP / CH₂Cl₂

3: LiN(TMS)2 / tetrahydrofuran

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol016696y